ReviewPLoS pathogens2025
How Klebsiella pneumoniae controls its virulence.
Review in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Hypermucoviscosity inJournal of bacteriology · 2026Review
- Associations of Biofilm Capacity with Antimicrobial Resistance and Virulence Genes inAntibiotics (Basel, Switzerland) · 2026Article
- Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella.PLoS pathogens · 2026Article
- Sugar import suppresses Klebsiella pneumoniae Mucoidy in a cAMP-CRP-dependent manner.Nature communications · 2026Article
- A dual-tier plasmid network model underpins the evolutionary success of pandemic Klebsiella pneumoniae ST11.Scientific reports · 2026Article
- Phosphorylation Modification Characteristics of Liver Injury-Related Proteins inPathogens (Basel, Switzerland) · 2026Article
- Distinct and shared impacts of virulence plasmids on the phenotype and transcriptome in convergent carbapenem-resistant and hypervirulentMicrobiology spectrum · 2026Article
- Clinical and Genomic Characterization of High-Risk Multidrug-ResistantMicroorganisms · 2026Article
- Emergence of hypervirulent Klebsiella pneumoniae ST111 with a novel virulence plasmid causing pyogenic liver abscess.BMC microbiology · 2026Article
- Molecular and mechanistic insights into the gut-liver axis inInfection and immunity · 2026Review
- Phenotypic and Transcriptomic Characterization of Host-Associated Responses in a Carbapenem-ResistantPathogens (Basel, Switzerland) · 2026Article
- Microbiome-mediated colonization resistance to and countermeasures of Klebsiella pneumoniae.Nature communications · 2026Article
- Molecular resistome profiling of multidrug-resistantBioinformation · 2026Article
- Prevalence and Antimicrobial Resistance ofInfection and drug resistance · 2026Article
- Virulence regulation in the fish pathogenFrontiers in cellular and infection microbiology · 2026Review
- Differential analysis of virulence and antibiotic resistance genes in ST11 CRKP and ST15 CRKP isolates from a tertiary hospital.Frontiers in microbiology · 2026Article
- Sugar Import SuppressesbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The bacterial pathogen Klebsiella pneumoniae is a serious public health threat due to its propensity to develop antimicrobial resistance (AMR), the emergence of hypervirulent strains able to cause community-acquired infections, and the more recent development of convergent strains that exhibit both traits. Pathogenesis in K. pneumoniae is attributed to a range of largely horizontally-acquired virulence or fitness factors that collectively mediate immune evasion, attachment, intermicrobial competition and nutrition in different niches within the host. An outstanding research question is how expression of these factors is coordinated during infection, and how this regulatory control varies in genomically distinct lineages. Here we review recent progress in understanding the regulators and networks that control K. pneumoniae virulence or host fitness factor expression, discuss the role of plasmid-chromosome regulatory crosstalk in pathogenesis, and explore the potential of new global approaches to enhance our understanding. This knowledge will be instrumental in accurately predicting virulence from genome sequence in new emergent K. pneumoniae lineages, in order to track and manage this priority pathogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.