Evidence map›Paper›PMID 40952957›Full record

Observational studyGerontology2025

Fatigue and Vitamin D Status in Frail Elderly with and without Cancer, and Healthy Controls of Different Ages: Results from the IMAGE Study.

Erik Dahlén, Christel Hedman, Akhirunnesa Mily, Arlisa Alisjahbana, Gabriela Spulber, Jenny Holmström-Edstedt, Peter Bergman, Marcus Buggert, Linda Björkhem-Bergman

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Gerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erik DahlénDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.
Christel HedmanPalliative Medicine, Stockholms Sjukhem, Stockholm, Sweden.
Akhirunnesa MilyCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Arlisa AlisjahbanaCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Gabriela SpulberDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.
Jenny Holmström-EdstedtUnit Aging, Theme Inflammation and Aging, Karolinska University Hospital, Karolinska University Hospital, Stockholm, Sweden.
Peter BergmanDepartment of Clinical Immunology and Transfusion Medicine, Medical Diagnostics Karolinska, Karolinska University Hospital, Stockholm, Sweden.
Marcus BuggertCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Linda Björkhem-BergmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVitamin D deficiency has previously been shown to be associated with cancer-related fatigue. If vitamin D deficiency affects fatigue in frail elderly has not been studied before. The aim of this study was to investigate associations between vitamin D, fatigue, frailty, and sarcopenia in frail elderly with cancer (FEC) and without cancer (FE) in comparison with healthy controls.

methodsBaseline data from the "IMmunity and AGE" (IMAGE) study were used. IMAGE is an observational, prospective study originally designed to study immunity in frail elderly. In this study, data on self-assessed fatigue (0-10), vitamin D, and muscle strength at baseline were used. Four groups were included: (1) healthy elderly (HE) ≥65 years old with a score of 1-3 on Clinical Frailty Scale (CFS); (2) FE ≥65 years old (CFS 4-9); (3) with advanced cancer (FEC); and (4) healthy controls 18-64 years old (HY).

resultsA total of 273 participants were included. HE had significantly higher vitamin D levels compared to FE and FEC, median 82 nmol/L compared to 54 and 47 nmol/L (p < 0.001 for both). FE and FEC were more fatigued, median 5 (IQR 4-8) and 7 (IQR 5-8), compared to HE, median 2 (IQR 0-4) (p < 0.001 for both). Regression models showed that low vitamin D was associated with increased fatigue (p < 0.001), frailty (p < 0.001), and reduced muscle strength (p < 0.05).

conclusionFatigue was common in frail elderly, with or without cancer, and was associated with low vitamin D. Vitamin D deficiency was associated with increasing frailty and reduced muscle strength.

Indexed as

FatigueFrail ElderlyFrailtyNeoplasmsVitamin DVitamin D DeficiencyAdolescentAdultAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedMuscle StrengthVitamin DFatigueFrail elderlySarcopeniaVitamin D

Identifiers

PMID40952957
PMCPMC12622988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.