Evidence map›Paper›PMID 40952758›Full record

ArticleThe American journal of bioethics : AJOB2025

Reproductive Autonomy in Light of Expanded Prenatal Genomic Testing.

Isabella Holmes, Kathryn MacKay, Rosalind McDougall, Jackie Leach Scully, Ainsley J Newson

Abstract read
PubMed Publisher
In one paragraph

Article in The American journal of bioethics : AJOB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Genomic Medicine and Individual Autonomy: Reflections on Knowledge Societies and Governmentality.International journal of environmental research and public health · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Isabella HolmesThe University of Sydney.ORCID 0000-0002-5822-7561
Kathryn MacKayThe University of Sydney.ORCID 0000-0001-9022-4558
Rosalind McDougallThe University of Melbourne.ORCID 0000-0002-3809-2575
Jackie Leach ScullyUniversity of New South Wales.ORCID 0000-0002-7637-1225
Ainsley J NewsonThe University of Sydney.ORCID 0000-0002-3460-772X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic-based testing in reproduction is expanding, with more tests offered to more people for more indications. These tests are offered in the name of reproductive autonomy. However, 'reproductive autonomy' is often interpreted to over-emphasize maximal choice and information, overlooking the role of relationships and structural influences. In this paper, we consider how reproductive autonomy can be conceptualized to be useful for challenges presented by expanded prenatal genomics. After critically examining the epistemological assumptions connecting (genomic) information and autonomy, as well as the ideological pressures these tests potentially intensify, we present and defend a more fitting approach to reproductive autonomy. Our account is characterized by relationality, substantivism, the fulfillment of certain institutional conditions, and the provision of adequate options. By providing deeper philosophical context to the way we understand reproductive autonomy in expanded prenatal genomic testing, our approach nuances how the offer and uptake of prenatal genomic testing should progress.

Indexed as

Genetic TestingGenomicsPersonal AutonomyPrenatal DiagnosisReproductionDecision MakingFemaleHumansPregnancyFeminist bioethicsgenomicspregnancyprenatal diagnosisrelationalityreproductive autonomy

Identifiers

PMID40952758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.