Trial reportEuropean geriatric medicine2026
Efficacy of two calcifediol supplementation regimens in older adults post-hip fracture surgery. A clinical trial.
Trial report in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03213886 (A Prospective Randomized Trial Comparing the Effects of 2 Vitamin D Supplementation Regimens in Elderly People After Hip Fracture Surgery), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Randomized Trial Comparing the Effects of 2 Vitamin D Supplementation Regimens in Elderly People After Hip Fracture Surgery
Who cites it
1 citing paper in PubMed.
- Vitamin D Deficiency in Hip Fracture Patients: Outcome-Specific Associations and Post-Fracture Management-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D deficiency is highly prevalent among older adults with hip fracture and may compromise recovery. This study evaluated the effectiveness of two calcifediol supplementation regimens in correcting serum 25-hydroxyvitamin D [25(OH)D] levels and supporting functional recovery.
methodsIn this randomized clinical trial, 50 patients aged ≥ 75 years with hip fracture and serum 25(OH)D < 30 ng/mL were assigned to receive calcifediol 266 μg daily for 5 days (intervention group, IG) or 266 μg weekly for 5 weeks (control group, CG). Primary endpoints were the proportion achieving 25(OH)D > 30 ng/mL, change in parathyroid hormone, and functional recovery assessed at discharge and at 3, 6, and 12 months post-fracture.
resultsThe mean age was 86 years; 64% were women. Baseline 25(OH)D was 13.3 ng/mL in the IG and 12.0 ng/mL in the CG. After one month, both groups showed increased concentrations (38.2 vs. 35.2 ng/mL; p = 0.50). PTH decreased more in the IG (43.5 vs. 75.2 pg/mL; p = 0.001). Approximately 50% of patients showed clinically meaningful functional improvement. Multivariate analysis indicated lower relative functional gain in CG participants who did not achieve optimal 25(OH)D levels (67.2 vs. 43.7; p = 0.06). No significant differences in long-term functional outcomes were observed between groups.
conclusionsBoth daily and weekly calcifediol regimens effectively corrected vitamin D deficiency in older adults with hip fracture. Functional improvement at discharge was observed in both groups and was clinically relevant.
trial registrationClinicalTrials.gov Identifier: NCT03213886 (Date of registration: 11/07/2017).
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