Evidence map›Paper›PMID 40952624›Full record

ArticleJournal of neuro-oncology2025

Piperlongumine induces meningioma cell death via the ROS-mediated endoplasmic reticulum stress and the alteration of the ubiquitin-proteasome system.

Nopporn Naewwan, Krajang Talabnin, Thanawat Trasaktaweesakul, Phattrara Khuansonthi, Pundit Asavaritikrai, Pitchanun Jaturutthaweechot, Chutima Talabnin

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nopporn NaewwanTranslational Medicine Program, Institute of Medicine, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand.
Krajang TalabninDepartment of Pathology, Institute of Medicine, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand.
Thanawat TrasaktaweesakulTranslational Medicine Program, Institute of Medicine, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand.
Phattrara KhuansonthiDepartment of Surgery, Institute of Medicine, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand.
Pundit AsavaritikraiDepartment of Surgery, Institute of Medicine, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand.
Pitchanun JaturutthaweechotSchool of Chemistry, Institute of Science, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand.
Chutima TalabninSchool of Chemistry, Institute of Science, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima, 30000, Thailand. chutima.sub@sut.ac.th.

Funding

Thailand Science Research and Innovation (TSRI), National Science, Research, and Innovation Fund (NSRF) 195616
6 · The paper itself

Abstract

purposeMeningiomas, the most common primary tumors of the central nervous system, are curable by surgical resection and radiotherapy. However, systemic therapeutic chemotherapy for meningiomas has not existed. Piperlongumine (PL), a natural alkaloid extracted from the long pepper (Piper longum), has emerged as a promising candidate for cancer treatment due to its multimodal anti-cancer effects. However, the effects of PL in meningiomas are limited.

methodsWe examined the anti-cancer effect of PL in vitro using primary benign meningioma cells and malignant meningioma cells. The underlying mechanism of PL in meningiomas was investigated through gene expression experiments at both mRNA and protein levels.

resultsPL inhibited meningioma cell growth, evidenced by inducing G2/M phase arrest via the up-regulation of cell cycle regulators including TP53 and CDKN1A/p21 and enhancing cell apoptosis via the up-regulation of cleaved caspase 3 and cleaved PARP1. PL-induced meningioma cell death was triggered via the activation of intracellular reactive oxygen species production leading to endoplasmic reticulum stress and the alteration of ubiquitin-proteasome system resulting in the accumulation of poly-ubiquitinated proteins.

conclusionThe present study indicates that PL has anti-cancer effect against meningiomas.

Indexed as

DioxolanesEndoplasmic Reticulum StressMeningeal NeoplasmsMeningiomaProteasome Endopeptidase ComplexReactive Oxygen SpeciesUbiquitinApoptosisCell DeathCell Line, TumorCell ProliferationHumansPiperidonesDioxolanesPiperidonespiperlongumineProteasome Endopeptidase ComplexReactive Oxygen SpeciesUbiquitinEndoplasmic reticulum stressMeningiomasPiperlongumineUbiquitin-proteasome system

Identifiers

PMID40952624

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.