ReviewTopics in current chemistry (Cham)2025
Recent Advances in the Synthesis of Spirooxindoles: A Comprehensive Review Organized by Ring Size, Heteroatom Incorporation, and Synthetic Approaches.
Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Spirooxindole Derivatives as Emerging Scaffolds in Drug Discovery: Synthetic Strategies, Structure-Activity Relationship, and Biological Activities.ChemMedChem · 2026Review
- Graphitic Carbon Nitride (g-CMolecules (Basel, Switzerland) · 2026Review
- Article
- Bifunctional Monothiosquaramide-Catalyzed Enantioselective Addition of Masked Acyl Cyanide to Isatins: Umpolung Strategy for the Total Synthesis of (Organic letters · 2026Article
- Synthesis of spiro-lactam hydrazones by clay catalysis: toxicity, antioxidant, hypolipidemic andRSC advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spirooxindole compounds have attracted considerable research interest due to their distinctive structural features and remarkable biological properties. In recent years, a wide range of synthetic strategies has been developed to construct spirooxindoles, particularly those featuring a spiro-carbon Linked to diverse Heterocyclic or carbocyclic frameworks, further enhancing their importance. Given the breadth of these synthetic approaches, a comprehensive review is crucial to providing a systematic overview of the field and facilitate access to various methodologies. This review provides a thorough analysis of current developments in spirooxindole synthesis, covering research published from 2020 to 2024. The classification is organized into four main sections based on the size of the ring attached to the spiro-carbon: three-membered, five-membered, six-membered, and seven-membered rings. These rings may be carbocyclic or may contain one or two heteroatoms, such as nitrogen, oxygen, or sulfur, further influencing the diversity of synthetic strategies and the properties of the resulting spirooxindoles.
Indexed as
Identifiers
40952617What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.