ArticleJournal of nephrology2025
The effect of chronic kidney disease on the association of tricuspid regurgitation with overall survival : Insights from SHEBAHEART big data.
Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
backgroundChronic kidney disease (CKD) is a common comorbidity among patients with tricuspid regurgitation, yet its impact on tricuspid regurgitation outcomes is underexplored. This study examines how CKD affects the relationship between severe tricuspid regurgitation and overall survival.
methodsThis is a retrospective cohort study of all adult patients (> 18 years old) evaluated at the Sheba Medical Center, between 2007 and 2022, who underwent transthoracic echocardiographic evaluation. It is based on the SHEBAHEART big data registry. Sheba Medical Center is the largest hospital in Israel with approximately 115,000 admissions per year. The echocardiographic reports together with the electronic medical records of all patients are the source for this study. Patients with missing creatinine data within one month of their echocardiography study, as well as those who underwent tricuspid regurgitation intervention, were excluded from the study. Patients were categorized into four groups, according to the presence and severity of tricuspid regurgitation and stratified by CKD stage. The primary outcome was all-cause mortality.
resultsThe study included 78,147 patients (median age 67, IQR 55-78), with 2989 (4%) having severe tricuspid regurgitation and 19,910 (25%) with an estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m
conclusionsThe association between severe tricuspid regurgitation and poor survival is stronger in advanced CKD patients and may be modulated through right ventricular function.
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