Evidence map›Paper›PMID 40952540›Full record

ArticleDiscover oncology2025

The involvement of exosomes in the tumorigenicity of breast cancer cell lines through the crosstalk between STAT3, Notch, and Wnt signaling pathways.

Shymaa Abdullah Mohamed, Toka M I Badawy, Menna Allah M K Hussein, Mohammed Salama, Yasser M El Kerm, Mohamed A Abdel Mohsen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shymaa Abdullah MohamedMolecular Biology Unit, Medical Technology Center, Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. shymaa.abdullah@alexu.edu.eg.
Toka M I BadawyApplied Medical Chemistry Department, Medical Research Institute, M.Sc, Alexandria University, Alexandria, Egypt.
Menna Allah M K HusseinApplied Medical Chemistry Department, Medical Research Institute, M.Sc, Alexandria University, Alexandria, Egypt.
Mohammed SalamaHistochemistry and Cell Biology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Yasser M El KermCancer Management and Research Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Mohamed A Abdel MohsenApplied Medical Chemistry Department, Medical Research Institute, M.Sc, Alexandria University, Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExosomes play a critical role in the tumor microenvironment by interacting with signaling pathways that facilitate breast cancer metastasis, particularly the STAT3 pathway. The STAT3 pathway is essential for tumor progression and aggressiveness, as it interacts with other pathways like Wnt and Notch in particular, triple-negative breast cancer (TNBC) which is the most aggressive form of breast cancer, with a poor prognosis and rapid metastasis. It is exciting to researchers because it is therapeutically challenging and highly invasive. As a result of the lack of specific treatment options, conventional therapy is widely used, which frequently results in relapse.

objectivesElucidate the critical roles of exosomes in modulating breast cancer behaviour and disease progression in TNBC through STAT3 signaling pathways. Specifically, it was focused on the interplay between STAT3 and Wnt or Notch signaling MATERIALS AND

methodsExosomes were isolated from one TNBC patient and characterized using electron microscopy and the western blotting technique. This study utilized two subtypes of breast cancer cell lines: non-TNBC and TNBC. AG490 treatment inhibited STAT3 signaling, and then after inhibition, tumorigenic behaviours were evaluated. Gene expression profiles related to the investigated signaling pathways, Wnt and Notch, were detected. THE RESULTS AND

conclusionExosomes significantly affect tumor behaviours and chemoresistance and manipulate signaling pathways associated with tumorigenesis, including Wnt/β-catenin and Notch. These results demonstrated the tumorigenic role of exosomes in the TNBC aggressiveness and suggest that their mechanisms may involve Wnt or Notch signaling mediated by the STAT3.

Indexed as

ExosomesNotch signaling pathwaySTAT3 signaling pathwayTriple negative breast cancerTumorigenic behaviorWnt signaling pathway

Identifiers

PMID40952540
PMCPMC12436252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.