Evidence map›Paper›PMID 40952498›Full record

ArticleMikrochimica acta2025

ZIF-8-derived double-shelled hollow ZnS nanocages: a new signal transducer for photoelectrochemical immunoassay of neuron-specific antigen-based neuroblastoma biomarker.

Zhaobin Zeng, Haibin Wang, Chongming Cai, Lin Xiang, Haohuan Zhou, Ziyi Xie, Bangming Guo

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Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhaobin ZengDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Haibin WangDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Chongming CaiDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Lin XiangDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Haohuan ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Ziyi XieDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China.
Bangming GuoDepartment of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People's Republic of China. a01855@gmu.edu.cn.

Funding

The First Affiliated Hospital of Gannan Medical University (China) with the Science and Technology Innovation Fund GNXYY203
6 · The paper itself

Abstract

Methods based on photoelectrochemical immunoassay have been utilized for the quantitative monitoring of neuron-specific antigen (NSE) with neuroblastoma patients, but most provide only low sensitivity. In this contribution, a simple and feasible photoelectrochemical immunoassay based on ZIF-8-derived double-shelled hollow ZnS nanocages (ZnS NCs) was applied to the split-type photocurrent measurement of NSE in biological fluids, accompanied by an enzyme-catalyzed system for synergistic amplification. Glucose oxidase (GOx)-labeled anti-NSE secondary antibody was utilized to form a sandwiched immunoreaction on capture antibody-coated microplate, whereas ZnS NCs with strong and stable photocurrents were employed to generate the detectable photocurrent. Subsequently, GOx catalyzed the glucose substrate to produce hydrogen peroxide, thereby causing the change in the photocurrent of double-shelled hollow ZnS nanocages. Followed by optimizing experimental conditions, the photoelectrochemical immunoassay displayed good photocurrent responses within the dynamic range 1.0-10000 pg mL

Indexed as

Biomarkers, TumorElectrochemical TechniquesNanostructuresNeuroblastomaSulfidesZeolitesZinc CompoundsAntibodies, ImmobilizedGlucose OxidaseHumansImmunoassayLimit of DetectionPhotochemical ProcessesReproducibility of ResultsAntibodies, ImmobilizedBiomarkers, TumorGlucose OxidaseSulfidesZeolitesZinc Compoundszinc sulfideDouble-shelled hollow ZnS nanocagesNeuroblastoma biomarkerNeuron-specific antigenPhotocurrent monitoringPhotoelectrochemical immunoassaySignal transducer

Identifiers

PMID40952498

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