Evidence map›Paper›PMID 40952481›Full record

ReviewUrologie (Heidelberg, Germany)2025

[Retroperitoneal lymphadenectomy (RPLND) for the treatment of testicular germ cell tumors-open or robotic? Pro open surgery : RPLND in the management of testis cancer].

Axel Heidenreich, David Pfister

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In one paragraph

Review in Urologie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Axel HeidenreichKlinik für Urologie, Uro-Onkologie, roboter-assistierte und spezielle urologische Chirurgie, Uniklinik Köln, Kerperner Str. 62, 50937, Köln, Deutschland. Axel.heidenreich@uk-koeln.de.
David PfisterKlinik für Urologie, Uro-Onkologie, roboter-assistierte und spezielle urologische Chirurgie, Uniklinik Köln, Kerperner Str. 62, 50937, Köln, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retroperitoneal lymphadenectomy (RPLND) represents an established surgical treatment option for patients with testicular germ cell tumors and might be performed at various clinical stages depending on individual risk factors. Typically, RPLND is performed via a trans- or extraperitoneal open approach with dissection of a unilateral or bilateral template. Since robot-assisted approaches have been established in uro-oncological surgery, the question arises whether there is already an established indication to perform robot-assisted RPLNDs (R-RPLND). International guidelines recommend that such a surgical procedure should only be performed for selected patients in testicular cancer referral centers by highly experienced testicular cancer surgeons. We reviewed the recently published data of R‑RPLND and we conclude that R‑RPLND is technically feasible and that it can be performed with equal complication rates if done in an expert center. However, there is no benefit in terms of oncological and functional outcome. Based on the results of multicenter trials and meta-analyses, antegrade ejaculation is only preserved in 65-70% of the patients, which is inferior to open surgery done in expert centers. Duration of surgery is significantly longer compared to open surgery. Oncological outcome following R‑RPLND is difficult to validate due to the short follow-up intervals and the selection of patients. Comparison of postchemotherapeutic R‑RPLND with open surgery is also hampered due to highly selected patients with only small residual masses and short follow-up periods. In summary, R‑RPLND should only be established in testicular cancer expert centers. Currently, we perform R‑RPLND especially for marker negative clinical stage IIA/B with lymph node metastases with a size of less or equal to 3 cm.

Indexed as

Lymph Node ExcisionNeoplasms, Germ Cell and EmbryonalRobotic Surgical ProceduresTesticular NeoplasmsHumansMaleRetroperitoneal SpaceTreatment OutcomeChemotherapyMalignant neoplasmsNonseminomasSeminomasTesticular neoplasms

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.