Evidence map›Paper›PMID 40952430›Full record

ArticleSurgery today2026

The second-drop eosinophil ratio is useful for the early detection of severe complications after pancreaticoduodenectomy.

Hironori Shiozaki, Shuichi Fujioka, Yuki Takano, Takashi Shimazaki, Machi Suka, Taro Sakamoto, Takeshi Gocho, Keitaro Nakamoto, Naoki Toya, Toru Ikegami

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hironori ShiozakiDepartment of Surgery, The Jikei University Kashiwa Hospital, 163-1 KashiwashitaKashiwa-shi, Chiba, 227-8567, Japan. hironori525@hotmail.co.jp.
Shuichi FujiokaDepartment of Surgery, The Jikei University Kashiwa Hospital, 163-1 KashiwashitaKashiwa-shi, Chiba, 227-8567, Japan.
Yuki TakanoDepartment of Surgery, The Jikei University Kashiwa Hospital, 163-1 KashiwashitaKashiwa-shi, Chiba, 227-8567, Japan.
Takashi ShimazakiDepartment of Public Health and Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-City, Tokyo, 105-8461, Japan.
Machi SukaDepartment of Public Health and Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-City, Tokyo, 105-8461, Japan.
Taro SakamotoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-City, Tokyo, 105-8461, Japan.
Takeshi GochoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-City, Tokyo, 105-8461, Japan.
Keitaro NakamotoDepartment of Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, 3-4-32 Todaijima, Urayasu, Chiba, 279-0001, Japan.
Naoki ToyaDepartment of Surgery, The Jikei University Kashiwa Hospital, 163-1 KashiwashitaKashiwa-shi, Chiba, 227-8567, Japan.
Toru IkegamiDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-City, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePancreaticoduodenectomy is associated with high morbidity, notably due to complications, such as postoperative pancreatic fistula and intra-abdominal hemorrhaging. The early detection of such complications is crucial for improving outcomes. The peripheral blood eosinophil ratio, which reflects the endogenous corticosteroid activity, may indicate physiological stress or inflammation. This study evaluated whether or not changes in the eosinophil ratio could predict postoperative complications.

methodsA retrospective review of patients who underwent pancreaticoduodenectomy between January 2011 and December 2020 at Jikei University Kashiwa Hospital was conducted. The postoperative eosinophil ratio trends were analyzed in relation to complications.

resultsAmong 200 patients, 85 experienced Clavien-Dindo grade ≥ III complications. A biphasic pattern in the eosinophil ratio was observed in these patients, with a secondary decline correlating with the onset of complications. Using a cutoff of 0.95%, the sensitivity, specificity, and area under the curve for predicting severe complications were 0.92, 0.92, and 0.96, respectively (95% confidence interval 0.93-0.99).

conclusionA sustained decrease in the peripheral blood eosinophil ratio was associated with severe postoperative complications. This marker may be useful for early detection, enabling prompt diagnostic and therapeutic intervention following pancreaticoduodenectomy.

Indexed as

Early DiagnosisEosinophilsPancreaticoduodenectomyPostoperative ComplicationsAdultAgedAged, 80 and overBiomarkersFemaleHumansLeukocyte CountMaleMiddle AgedPancreatic FistulaRetrospective StudiesSensitivity and SpecificityBiomarkersEosinophilsPancreaticoduodenectomyPostoperative complications

Identifiers

PMID40952430

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