Evidence map›Paper›PMID 40952390›Full record

ArticleAntimicrobial agents and chemotherapy2025

Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressing

Mariska de Munnik, Karina Calvopiña, Patrick Rabe, Christopher J Schofield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mariska de MunnikChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-0350-395X
Karina CalvopiñaChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, United Kingdom.
Patrick RabeChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-3448-9559
Christopher J SchofieldChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0290-6565

Funding

Biotechnology and Biological Sciences Research Council BB/M011224/1Tres Cantos Open Lab Foundation TC297Wellcome TrustWellcome Trust 106244/Z/14/ZWellcome Trust 227298/Z/23/Z
6 · The paper itself

Abstract

β-lactams demonstrate promising

Indexed as

Anti-Bacterial Agentsbeta-LactamsMycobacterium smegmatisPenicillin-Binding ProteinsPeptidyl TransferasesBacterial ProteinsMeropenemMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsMeropenemPenicillin-Binding ProteinsPeptidyl Transferasesantimicrobial resistance (AMR)bacterial cell wall biosynthesisbeta-lactam antibioticLdtMt2l,d-transpeptidaseMycobacterium smegmatisMycobacterium tuberculosisPBP3penicillin-binding proteinpeptidoglycan

Identifiers

PMID40952390
PMCPMC12486854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.