Evidence map›Paper›PMID 40952159›Full record

ArticleAdvanced healthcare materials2026

Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.

Adrián Villamarin-Ortiz, Christopher F Reiche, Frederick Federer, Andrew M Clark, John D Rolston, Cristina Soto-Sánchez, Eduardo Fernandez, Steve Blair, Alessandra Angelucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Adrián Villamarin-OrtizBioengineering Institute, University Miguel Hernández, Elche, 03202, Spain.
Christopher F ReicheDepartment of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, 84112, USA.
Frederick FedererDepartment of Ophthalmology and Visual Science, Moran Eye Institute, University of Utah, Salt Lake City, UT, 84132, USA.
Andrew M ClarkDepartment of Ophthalmology and Visual Science, Moran Eye Institute, University of Utah, Salt Lake City, UT, 84132, USA.
John D RolstonDepartment of Neurosurgery and Biomedical Engineering, University of Utah, Salt Lake City, UT, 84132, USA.
Cristina Soto-SánchezBioengineering Institute, University Miguel Hernández, Elche, 03202, Spain.
Eduardo FernandezBioengineering Institute, University Miguel Hernández, Elche, 03202, Spain.
Steve BlairDepartment of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, 84112, USA.
Alessandra AngelucciDepartment of Ophthalmology and Visual Science, Moran Eye Institute, University of Utah, Salt Lake City, UT, 84132, USA.ORCID 0000-0002-1957-2231

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responsesR01EY026812 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ANGELUCCI, ALESSANDRA · 2016 to 2025
$4.7M
Connectivity and function of inhibitory neurons in the primate visual cortexR01EY031959 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Alessandra Angelucci · 2020 to 2026
$3.0M
Development of an integrated array for simultaneous optogenetic stimulation and electrical recording to study cortical circuit function in the non-human primate brainU01NS099702 · NINDS · UNIVERSITY OF UTAH · PI ANGELUCCI, ALESSANDRA, BLAIR, STEVEN M · 2016 to 2018
$2.4M
European Union's Horizon 2020 Research and Innovation Programme 899287 (NeuraViPeR)Generalitat Valenciana CIPROM/2023/25Mary Boesche EndowmentMinisterio de Ciencia, Innovación y Universidades PDC2022-133952-100Ministerio de Ciencia, Innovación y Universidades PID2022-141606OB-I00National Science Foundation IOS 175543NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY026812NEI NIH HHS R01 EY031959NIH HHS P30 EY014800NIH HHS R01 EY026812NIH HHS R01 EY031959NINDS NIH HHS U01 NS099702Research to Prevent Blindness Inc. (or RPV)
6 · The paper itself

Abstract

Optogenetics has transformed neural circuit studies, but its application to large-brained species like non-human primates (NHPs) remains limited. A major challenge in NHP optogenetics is delivering light to large volumes of deep neural tissue with high spatiotemporal precision, without affecting superficial tissue. To overcome these limitations, we recently developed and tested in vivo in NHP cortex, the Utah Optrode Array (UOA). This is a 10 × 10 array of penetrating glass shanks, tiling a 4 × 4 mm

Indexed as

Cerebral CortexOptogeneticsAnimalsAstrocytesMacaca mulattaMaleMicrogliaNeuronsGFAP immunohistochemistryIba1 immunohistochemistryneural prosthesesnon‐human primatesoptogeneticstissue damage

Identifiers

PMID40952159
PMCPMC12817112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.