ArticleJournal of virology2025
Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production.
Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Human herpesvirus 6B (HHV-6B), a member of the IMPORTANCE: HHV-6B is a virus that primarily infects T cells and can cause illnesses like exanthem subitum and is linked to neurological conditions such as multiple sclerosis. Like other herpesviruses, HHV-6B likely has special proteins that help it avoid the body's immune defenses, such as the IFNβ signaling pathway, which plays a key role in fighting viral infections. However, how these viral proteins interfere with the immune response is not yet fully understood. In this study, we discovered that one of the HHV-6B proteins, U65, blocks the production of IFNβ, weakening the antiviral defenses. We also found that two human proteins, hCG_2039566 and H2AC7, promote the immune system, but U65 prevents them from doing so. This study reveals a new way that HHV-6B escapes the immune system, providing insight into how the virus efficiently establishes infections and how we might target its ability to evade immunity.
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