Evidence map›Paper›PMID 40952117›Full record

ArticleJournal of virology2025

Sensing of Ebinur Lake virus by distinct pattern recognition receptors dictates cell-type specific innate immunity and pathogenesis.

Jia-Peng Zou, Su-Yun Wang, Han Xia, Zhi-Sheng Xu, Wei-Wei Luo, Yan-Yi Wang

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia-Peng ZouState Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China.ORCID 0009-0002-9749-8134
Su-Yun WangState Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China.
Han XiaState Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China.ORCID 0000-0001-9932-6040
Zhi-Sheng XuState Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China.
Wei-Wei LuoState Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China.ORCID 0000-0002-8541-4274
Yan-Yi WangState Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China.ORCID 0000-0002-9316-2417

Funding

Key Research Program of Frontier Science, Chinese Academy of Sciences ZDBS-LY-SM033National Key Research and Development Program of China 2023YFC2306100, 2021YFA1302400, 2022YFC2303300Natural Science Foundation of Wuhan 2024040701010068Strategic Priority Research Program XDB0490000
6 · The paper itself

Abstract

Ebinur Lake virus (EBIV) is a recently identified orthobunyavirus with broad host range and zoonotic potential, posing a public health risk. However, the mechanisms underlying EBIV pathogenesis and host innate immune responses remain unclear. Here, we investigated the pattern recognition receptors (PRRs) responsible for sensing EBIV infection and subsequent pathogenesis. EBIV infects diverse cell types and exhibits broad tissue tropism

Indexed as

Immunity, InnateReceptors, Pattern RecognitionA549 CellsAnimalsDEAD Box Protein 58HEK293 CellsHost-Pathogen InteractionsHumansInterferon-Induced Helicase, IFIH1Interferon Type IMiceReceptors, ImmunologicRNA, ViralDEAD Box Protein 58IFIH1 protein, humanInterferon-Induced Helicase, IFIH1Interferon Type IReceptors, ImmunologicReceptors, Pattern RecognitionRIGI protein, humanRNA, Viralhost-pathogen interactionsinnate immunityorthobunyaviruspathogen-associated molecular patternspattern recognition receptors

Identifiers

PMID40952117
PMCPMC12548452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.