ArticleJournal of virology2025
A novel accessory gene product of tick-borne Dhori-Orthomyxovirus, encoded by overlooked spliced transcripts of RNA segment 6.
Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dhori virus (DHOV) ( IMPORTANCE: Dhori and Thogoto viruses are tick-transmitted orthomyxoviruses comprising two clades differing in the coding strategy of their matrix protein. The recent detection of Dhori-like Bourbon virus (BRBV) highlighted their zoonotic potential. M of Dhori-like viruses is translated from a collinear transcript of the smallest of the six genomic ssRNA segments. Thogoto-like viruses express M from spliced transcripts, and unspliced transcripts encode an extended ML protein. No analogous splicing event or additional gene product has been characterized for Dhori-like viruses, yet. Here, we describe the hitherto overlooked splicing of segment 6 transcripts of Dhori virus. The 5'-part of the processed transcript is collinear with the M-ORF, whereas splicing shifts it into a -1 frame. The predicted product M2-248 was detected in infected cells. Recombinant Dhori virus lacking M2 was attenuated
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