Evidence map›Paper›PMID 40952045›Full record

ArticleAllergy2026

Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes.

Carla Rebeca Da Silva Sena, Gabriela Martins Costa Gomes, Noëmi Künstle, Olga Gorlanova, Andrea Marten, Sven Schulzke, Florian Wyler, Vanessa E Murphy, Paul D Robinson, Peter D Sly and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Carla Rebeca Da Silva SenaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Gabriela Martins Costa GomesAsthma & Breathing Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Noëmi KünstleUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Olga GorlanovaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-3153-7404
Andrea MartenUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Sven SchulzkeUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Florian WylerUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Vanessa E MurphyAsthma & Breathing Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3282-1324
Paul D RobinsonDepartment of Respiratory Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia.
Peter D SlyChildren's Health and Environment Program, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Jakob UsemannUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Benjamin StoecklinUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Ruth SteinbergUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Sophie YammineUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Loretta MüllerDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Philipp LatzinUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Pablo SinuesUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Peter G GibsonAsthma & Breathing Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Joerg MattesAsthma & Breathing Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Adam CollisonAsthma & Breathing Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Urs FreyUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-3773-2822
BILD and BLT Study Groups

Funding

European Respiratory SocietyEuropean Union H2020Hunter Children's Research FoundationMarie Sklodowska-Curie Grant 847462National Health and Medical Research Council Australia 1060983National Health and Medical Research Council Australia 1081667National Health and Medical Research Council Australia 2004514Priority Research Centre GrowUpWellRebecca L. Cooper Medical Research FoundationSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030_204717
6 · The paper itself

Abstract

backgroundIn utero mechanisms related to oxidative stress response, inflammation, and extracellular matrix turnover may influence fetal lung development in the offspring of asthmatic mothers. Therefore, we aimed to determine whether levels of cord blood proteins differ between the offspring of asthmatic and nonasthmatic mothers. In addition, we aimed to examine if these proteins are associated with infant lung function, bronchiolitis hospitalization in infancy, and asthma at six years.

methodsWe compared protein levels of infants (n = 715) from the Swiss Basel-Bern Infant Lung Development and the Australian Breathing for Life Trial birth cohorts using Tobit regression and network analyses. Using adjusted linear and logistic regression, we determined their association with postnatal infant lung function, bronchiolitis hospitalization in infancy, and asthma at six years.

resultsInfants born to asthmatic mothers had lower levels of matrix metalloproteinase-9 (MMP-9, β-coefficient [β] -0.67, 95% confidence interval [-1.07; -0.27] p

conclusionsProtein levels differed between offspring of asthmatic and non-asthmatic mothers. These markers were associated with postnatal lung function, bronchiolitis hospitalization, and asthma.

Indexed as

AsthmaBiomarkersPrenatal Exposure Delayed EffectsAdultBronchiolitisChildFemaleFetal BloodHumansInfantInfant, NewbornMaleMothersPregnancyRespiratory Function TestsBiomarkersasthmaasthma during pregnancybronchiolitisinfant lung functionproteins

Identifiers

PMID40952045
PMCPMC12773685

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.