Evidence map›Paper›PMID 40951924›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.

Lucy L Gibson, Lea T Grinberg, Victor R Paes, Christoph Mueller, Renata E P Leite, Paula Villela Nunes, Alberto F O Justo, Carlos A Pasqualucci, Eduardo Ferriolli, Dag Aarsland and 1 more

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Efficacy of transcranial alternating current stimulation on cognitive function in patients with dementia: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Review
  3. Post mortem MRI of cholinergic white matter pathways across neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Review
  5. Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lucy L GibsonKing's College London, Centre of Healthy Brain Ageing, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, London, UK.ORCID 0000-0002-9815-3616
Lea T GrinbergMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Victor R PaesDepartment of Pathology, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.
Christoph MuellerKing's College London, Centre of Healthy Brain Ageing, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, London, UK.
Renata E P LeiteDepartment of Pathology, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.
Paula Villela NunesDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.
Alberto F O JustoDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.
Carlos A PasqualucciDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.
Eduardo FerriolliDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.
Dag AarslandKing's College London, Centre of Healthy Brain Ageing, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, London, UK.
Claudia K SuemotoDivision of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, Brazil.

Funding

Alzheimer's Association AARG-20-678884Fundação de Apoio a Pesquisa do Estado de São Paulo 21/14171-8
6 · The paper itself

Abstract

backgroundMixed neuropathology is common in dementia, but the clinical implications for neuropsychiatric symptoms (NPSs) are not well characterized.

methodsIn a population-based post mortem study, cases with Alzheimer's disease neuropathological change (ADNC) and Lewy body disease (LBD) were identified with any comorbid neuropathology (limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy neuropathological change (LATE-NC), cerebrovascular disease, LBD, and ADNC, respectively). Post mortem interviews collected information regarding NPSs and cognition to explore associations between each co-pathology and NPSs across the whole cohort, as well as in participants without dementia.

resultsCo-existing neuropathology was frequent, even among individuals without clinical dementia. In cases with ADNC, comorbid neocortical LBD pathology was associated with hallucinations, regardless of cognitive status. However, ADNC co-pathology in LBD was linked to a greater NPS burden in the full cohort but not in individuals without dementia. DISCUSSION: Lewy bodies are associated with hallucinations independent of cognitive impairment, whereas ADNC co-pathology may contribute to NPS only when widespread and associated with cognitive dysfunction. HIGHLIGHTS: Neuropathological heterogeneity is high even in clinical stages without dementia. Neocortical but not limbic or brainstem LBD co-pathology is associated with hallucinations. LBs are associated with hallucinations independent of cognitive status. ADNC co-pathology is not associated with NPSs in LBD without dementia. LATE co-pathology is associated with increased risk of dementia but not NPS. Vascular co-pathology is associated with increased risk of delusions in ADNC.

Indexed as

Alzheimer DiseaseBrainHallucinationsLewy Body DiseaseAgedAged, 80 and overCognitive DysfunctionCohort StudiesComorbidityFemaleHumansMaledementia with Lewy bodiesneuropathologyneuropsychiatric symptoms

Identifiers

PMID40951924
PMCPMC12434609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.