ReviewFrontiers in fungal biology2025
Regulation of melanin production in fungi.
Review in Frontiers in fungal biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Fungal melanin as a bioactive biopolymer: structural diversity, oxidative stress modulation, anticancer mechanisms, and therapeutic perspectives.RSC advances · 2026Review
- A Review of the Therapeutic Challenges and Novel Treatment Options in Mitigating Invasive Mycosis Associated withJournal of fungi (Basel, Switzerland) · 2026Review
- Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach.World journal of microbiology & biotechnology · 2026Review
- MelC tyrosinase-dependent enzymatic synthesis of functional melanins from phenolic monomers.Journal of biological engineering · 2026Article
- Nutrient utilization and degradative enzyme activity of the dragon fruit canker pathogen,Microbiology (Reading, England) · 2026Article
- Dismantling darkness: interdisciplinary perspectives on melanin degradation.World journal of microbiology & biotechnology · 2026Review
- Genomic-Driven Identification of Conserved Biosynthetic Gene Clusters inMetabolites · 2026Article
- Melanin and Neuromelanin in Humans: Insights Across Health, Aging, Diseases, and Unexpected Aspects of Fungal Melanogenesis.Biomolecules · 2025Review
- In Vitro Evaluation of the Antifungal Activity ofPlants (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanin is a dark macromolecule found in organisms ranging from animals to fungi and plants. In fungi, melanin is a secondary metabolite that is not essential per se for growth but does provide various benefits that facilitate adaptation to stressful conditions such as UV light, desiccation, oxygen radicals, and extreme temperatures. The biosynthetic pathways of most types of melanin are known and documented, but the regulation of those pathways is not well understood. In fungi, known pathways for melanin production include those directing the synthesis of 1,8-DHN melanin and L-DOPA melanin, as well as the tyrosine degradation pathway. Genetic studies have identified structural genes and enzymes that play a role in these different melanin biosynthesis pathways. Recent studies have focused on the roles of various transcription factors (TFs) and signaling circuits (e.g., cAMP/PKA and the HOG pathway) in regulating the expression of the biosynthetic pathways. The review will provide insights into what is known about these TFs and regulatory circuits in diverse fungi in an attempt to identify common themes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.