ArticleTherapeutic advances in musculoskeletal disease2025
Comparison of thoracic vertebrae and L1 CT attenuation in predicting osteoporosis using opportunistic chest CT.
Article in Therapeutic advances in musculoskeletal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Computed tomography-measured trabecular attenuation at first lumbar vertebra as a surrogate marker of bone mineral density and osteoporosis in patients undergoing hemodialysis.Renal failure · 2026Article
- Screening performance of sternal CT attenuation for opportunistic osteoporosis.BMC musculoskeletal disorders · 2026Article
- Standardizing attenuation across tube voltages and vertebral levels for opportunistic osteoporosis screening on low-dose chest CT.Radiology advances · 2026Article
- Feasibility of opportunistic bone health assessment using low-dose CT trabecular attenuation andFrontiers in endocrinology · 2026Article
- Artificial intelligence in osteoporosis assessment using CT imaging: a scoping review.Frontiers in medicine · 2026Review
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8 authors.
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Abstract
Background: Since dual-energy x-ray absorptiometry (DXA) is currently the most commonly used reference standard, most previous studies using computed tomography (CT) attenuation values to predict osteoporosis have chosen abdominal CT images. A few studies have investigated whether the thoracic vertebrae can be independently used for the identification of osteoporosis compared to the lumbar vertebrae. Objective: To investigate whether the attenuation values of thoracic vertebrae measured using artificial intelligence (AI) on chest CT would independently predict osteoporosis identification, considering central DXA as a reference standard. Design: This was a cross-sectional study. Methods: A total of 553 participants (353 men and 200 women) who underwent chest CT and DXA within 1 day were included. The attenuation values (HU) of the T7-12 vertebrae and L1 vertebra were obtained by AI. The effects of the clinical baseline data and attenuation values among the normal, osteopenia, and osteoporosis groups were compared. The correlation between attenuation and bone mineral density (BMD) values was analyzed, and the diagnostic performance of thoracic and first lumbar vertebrae attenuation values for diagnosing osteopenia or osteoporosis was further explored. Results: The CT attenuation values of T7-12 and L1 vertebrae showed positive correlation with Conclusion: Opportunistic screening is a valid method for predicting osteopenia or osteoporosis. As a rapid and effective tool, T10-12 vertebral attenuation measures can be incorporated to predict osteoporosis and identify patients who may benefit from further investigations using DXA based on routine clinical chest CT examinations.
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