ArticleJournal of Indian Society of Periodontology
Combination of metronidazole and green tea extract-loaded nanoparticles: Formulation, optimization,
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The study aimed to enhance the efficacy of periodontal treatment through the development of dual drug-loaded nanoparticles (NPs) of metronidazole (MET) and green tea extract (GTE). Materials and Methods: The NPs were prepared by solvent displacement, optimized by central composite rotatable design. The particle size, polydispersity index (PDI), and entrapment efficiency were assessed. The cell viability was assessed using the L929 mouse fibroblast cell lines. In addition, texture analysis, flux, and permeability coefficient of MET and GTE gel were measured. Minimum inhibitory concentration (MIC) was assessed on isolates obtained from periodontal patients. Hen's egg test-chorioallantoic membrane (HET-CAM) study was conducted to assess the irritability and tolerability of NPs. Results: The optimized NPs had a mean particle size of 171.0 ± 49.34 nm, a mean PDI of 0.383 ± 0.907, and a high entrapment efficacy of 89% ± 0:25%. Cell viability assay demonstrated 93.8% viability on mouse fibroblast cell lines. Texture analysis of NP-loaded gel showed high cohesiveness, less firmness, and consistency. The flux and permeability coefficient of MET and GTE was found to be 9.084 µg/h/cm Conclusions: Dual-drug-loaded NPs exhibited significant antimicrobial activity against periodontal pathogens and demonstrated promising potential to enhance the clinical outcomes of periodontal therapy.
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