ArticleJournal of Indian Society of Periodontology
Microbial overlap in dental plaque and tumor tissue of esophageal cancer patients: A pilot study.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Microbial dysbiosis has been shown to be involved in various types of gastrointestinal cancers, but there is a dearth of strong studies linking the oral microbiome imbalance with esophageal cancer (EC). Objectives: The main objective of the study was to identify the link between oral microbiome and EC. Materials and Methods: Twelve suspected EC and two healthy control patients were recruited. After the histological confirmation of EC, four confirmed EC patient samples and two healthy control samples were subjected to 16S metagenomics study using the Oxford Nanopore Technology sequencing platform. Results: Species richness of microbial community was higher in the healthy controls followed by diseased plaque, tumor tissue and adjacent tissue. Conclusion: Our study suggests an association between oral microbiome and EC. The prevalence of same microbial genus in the oral cavity (dental plaque) and tumor tissue depicts a possible link. Our study opens the plausible microbe-based biomarker screening of EC.
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