ArticleJournal of Indian Society of Periodontology
Evaluation of the impact of curcumin concentrations on the viability of human periodontal ligament cells: An
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Periodontal disease is a chronic inflammatory condition that leads to the destruction of periodontal tissues, exacerbated by bacterial lipopolysaccharide (LPS). Current therapeutic approaches seek to reduce inflammation and promote regeneration. Curcumin, a natural polyphenol with anti-inflammatory and antioxidant properties, may offer a biocompatible alternative for periodontal regeneration by protecting human periodontal ligament cells (hPDLCs) from inflammatory damage. Materials and Methods: The present Results: Curcumin treatment did not significantly impact cell viability in hPDLCs under noninflammatory conditions, with viability rates exceeding 94%. In LPS-stimulated cells, curcumin at 2.5 µM and 5 µM significantly improved viability from 60.1% (LPS only) to 80.1% and 87.6%, respectively. Morphological assessment revealed that curcumin mitigated LPS-induced cellular damage, promoting normal cell structure and growth. Conclusion: Curcumin demonstrates potential as a therapeutic agent for periodontal regeneration by enhancing cell viability and counteracting LPS-induced cytotoxicity in hPDLCs. This study supports curcumin's role in creating a microenvironment conducive to periodontal tissue repair and highlights its promise for future applications in periodontal therapy.
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