Evidence map›Paper›PMID 40951711›Full record

ArticleWorld journal of stem cells2025

Entering the era of living biopharmaceuticals for treating knee osteoarthritis: A systematic review and network meta-analysis.

Moaz Safwan, Mariam Safwan Bourgleh, Lubabah Baroudi, Aseel Almsned, Rawan AlBalawi, Batoul Aibour, Shahad AlFawaz, Safwan M Bourgleh, Khawaja Husnain Haider

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Moaz SafwanDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Mariam Safwan BourglehDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Lubabah BaroudiDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Aseel AlmsnedDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Rawan AlBalawiDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Batoul AibourDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Shahad AlFawazDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
Safwan M BourglehDepartment of Orthopedic Surgery, Hotat Sudair General Hospital, Second Health Cluster, Riyadh 15333, Saudi Arabia.
Khawaja Husnain HaiderDepartment of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. khhaider@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKnee osteoarthritis (KOA) is a leading cause of arthritis-related morbidity. Mesenchymal stem cells (MSCs), as living biopharmaceuticals, have emerged as a potential treatment option due to their anti-inflammatory and immunomodulatory properties.

aimTo compare the safety and efficacy of allogenic MSCs (

methodsWe conducted a systematic review and network meta-analysis to compare the safety and efficacy of

resultsNineteen RCTs involving 1216 patients with KOA met the inclusion criteria of the study. The network meta-analysis showed that

conclusion

Indexed as

BiopharmaceuticalsKnee osteoarthritisLiving biodrugsMesenchymal stem cellsMeta-analysisNetworkStem cells

Identifiers

PMID40951711
PMCPMC12427084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.