Evidence map›Paper›PMID 40951710›Full record

ReviewWorld journal of stem cells2025

Advances in mesenchymal stem cell-based therapies for recurrent spontaneous abortion.

Yi Xiao, Fan-Yu Zeng, Zhen-Yu Chen, Feng Zhao, Jing-Li Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mesenchymal stem cells for recurrent miscarriage.Journal of translational medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi XiaoDepartment of Obstetrics and Gynecology, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China.
Fan-Yu ZengDepartment of Obstetrics and Gynecology, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China.
Zhen-Yu ChenDepartment of Obstetrics and Gynecology, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China.
Feng ZhaoDepartment of Basic Medical, China Medical University, Shenyang 110000, Liaoning Province, China.
Jing-Li SunDepartment of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), Shenyang 110000, Liaoning Province, China. zg3416@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Young women's physical and mental health is seriously impacted by recurrent spontaneous abortion (RSA), a prevalent obstetric complication that is becoming more commonplace worldwide. Therefore, a thorough investigation into the pathophysiology of RSA and the development of novel therapeutic strategies are imperative. Recent developments suggest that mesenchymal stem cell (MSC)-based therapies may be viable for addressing RSA. Through a variety of mechanisms, the immunological circumstances at the maternal-fetal contact can be altered, including regulating immune cell homeostasis, enhancing immune tolerance, alleviating inflammatory responses, promoting angiogenic processes, and promoting tissue regeneration. MSCs exhibit a remarkable capacity for multi-differentiation that could enhance pregnancy outcomes. This article provides compelling studies supporting the efficacy of MSC-based therapies in improving pregnancy outcomes in women with RSA.

Indexed as

ImmuneMaternal-fetalMechanismMesenchymal stem cellsOutcomeRecurrent spontaneous abortionTherapyTreatment

Identifiers

PMID40951710
PMCPMC12427085

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.