Evidence map›Paper›PMID 40951709›Full record

ReviewWorld journal of stem cells2025

Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases.

Chen-Xu Cui, Xiao-Nan Shao, Yang-Yang Li, Liang Qiao, Jun-Tang Lin, Li-Hong Guan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen-Xu CuiStem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
Xiao-Nan ShaoStem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
Yang-Yang LiStem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
Liang QiaoStem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
Jun-Tang LinStem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
Li-Hong GuanStem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of neuronal function and structure, leading to severe morbidity and mortality. Current therapeutic approaches are ineffective at stopping or reversing disease progression. Stem cell therapy has emerged as a promising candidate in research and treatment. Mesenchymal stem cells (MSCs) are considered ideal candidates for regenerative medicine because of their high proliferation rate and multi-differentiation potential. MSCs can differentiate into neurons and glial cells, modulate immune responses, and reduce inflammation, and their exosomes can promote neural repair and regulate neuronal function; thus, MSCs offer unique advantages for treating neurodegenerative diseases. However, challenges remain in optimizing cell delivery methods, ensuring the long-term survival and integration of transplanted cells, and fully understanding their therapeutic effects. This article primarily outlines the functions of MSCs in neurodegenerative diseases, with the intention that further research will fully harness their potential and translate these findings into clinical applications, offering new hope for patients suffering from neurodegenerative diseases.

Indexed as

ImmunomodulationMesenchymal stem cellsNeurodegenerative diseaseParacrineStem cell therapy

Identifiers

PMID40951709
PMCPMC12427058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.