ReviewWorld journal of stem cells2025
Roles of intestinal stem cells in inflammatory bowel disease pathogenesis.
Review in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Exclusive enteral nutrition containing transforming growth factor-β improves intestinal barrier function in a colitis mouse model.Journal of pediatric gastroenterology and nutrition · 2026Article
- Vitamin D and Intestinal Diseases: Impact on Intestinal Immunity and Gut Barrier Function.Diseases (Basel, Switzerland) · 2026Review
- Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development.Cells · 2026Review
- Review
- Stem cell-based tactics in the remodeling and treatment of intestinal diseases.Stem cell research & therapy · 2026Review
- Protective Effects of Milk-Derived Extracellular Vesicles on Colitic Mice via ceRNA Network Involving lncRNAs and circRNAs.Foods (Basel, Switzerland) · 2026Article
- Cell cycle dysregulation: a central hub in colitis-associated colorectal carcinogenesis.Frontiers in immunology · 2026Review
- Bidirectional Crosstalk Between Intestinal Epithelium and Immune Microenvironment in Inflammatory Bowel Disease: Mechanisms and Therapeutic Implications.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD), consisting primarily of ulcerative colitis and Crohn's disease, is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. The pathogenesis of IBD has been thoroughly studied throughout the past few decades, such as defective gut epithelial barrier, immune responses, genetic predisposition, infections, and dysbiosis. Recent studies have revealed the unexpected importance of intestinal stem cells (ISCs) in the pathophysiology of IBD. The rapid recovery and continuous self-renewal of intestinal epithelial cells depend on ISCs within the crypts. Proliferation and differentiation of ISCs is an important cytological basis for repairing damaged intestinal mucosa. Unfortunately, as a new therapeutic goal in IBD, mucosal healing is difficult to achieve with current treatments. Stem cell therapy is an emerging treatment for IBD that allows mucosal healing by rebuilding the mucosal barrier. In this review, we present the current research progress on the role of ISCs in IBD and discuss stem cell-based therapies that have been specifically designed for its treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.