Evidence map›Paper›PMID 40951683›Full record

ReviewEngineering in life sciences2025

Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing.

Alperen Alpural, Ilgin Kimiz-Gebologlu, Mayur Parekh, Esra Imamoglu, Zulfiqur Ali, Ozlem Yesil-Celiktas

Abstract readReview
In one paragraph

Review in Engineering in life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alperen AlpuralDepartment of Bioengineering Faculty of Engineering Ege University Izmir Türkiye.
Ilgin Kimiz-GebologluDepartment of Bioengineering Faculty of Engineering Ege University Izmir Türkiye.
Mayur ParekhHealthcare Innovation Centre School of Health and Life Sciences Teesside University Middlesbrough, Tees Valley UK.
Esra ImamogluDepartment of Bioengineering Faculty of Engineering Ege University Izmir Türkiye.
Zulfiqur AliUniversity of Cumbria Carlisle UK.
Ozlem Yesil-CeliktasDepartment of Bioengineering Faculty of Engineering Ege University Izmir Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial bioprocessing is a key technology for the production of a wide range of biomolecules, including proteins, enzymes, antibiotics, and other bioactive compounds. In recent years, there has been an increasing interest in using microfluidic platforms for bioprocessing, due to the ability to precisely control and manipulate fluids at the microscale. Microfluidics offers a transformative platform for the manufacturing of biomolecules intended for clinical applications by addressing key technical challenges in scalability, precision, reproducibility, and the ability to study complex biological systems. In this review, various methods used to fabricate microfluidic platforms and the current state-of-the-art in the synthesis/production of biopharmaceuticals, polymers, bioactive compounds, and real-time monitoring in microscale bioprocesses are discussed. Additionally, the future trends and directions are highlighted. Overall, we envisage the utilization of microfluidic platforms to advance the field of microbial bioprocessing and applications in the biomedical field.

Indexed as

biomedical applicationsbioprocessmicrofluidicsmicroreactorreal‐time monitoringsensors

Identifiers

PMID40951683
PMCPMC12425123

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.