Evidence map›Paper›PMID 40951489›Full record

ArticleNarra J2025

Colchicine attenuates chemical hypoxia-induced pyroptosis through downregulation of nuclear factor kappa B and caspase-1 in cardiomyocytes.

Budi Satrijo, Mohammad S Rohman, Aulanni'am Aulanni'am, Hidayat Sujuti, Bayu Lestari

Abstract read
In one paragraph

Article in Narra J, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Budi SatrijoDoctoral Program in Medical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Mohammad S RohmanDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Aulanni'am Aulanni'amDepartment of Chemistry, Faculty of Sciences, Universitas Brawijaya, Malang, Indonesia.
Hidayat SujutiDepartment of Ophthalmology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Bayu LestariBrawijaya Cardiovascular Research Centre, Universitas Brawijaya, Malang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) is the leading cause of mortality worldwide. During MI, cardiomyocyte necrosis and inflammation are crucial in the post-MI cardiac remodeling process, including pyroptosis. Although colchicine is a well-known anti-inflammatory drug that has been clinically studied in the context of MI, its role in cardiac pyroptosis remains unclear. The aim of this study was to investigate the role of colchicine in pyroptosis in vitro, using CoCl

Indexed as

Caspase 1ColchicineMyocytes, CardiacNF-kappa BPyroptosisTubulin ModulatorsAnimalsCell HypoxiaCell LineDown-RegulationInterleukin-18In Vitro TechniquesRatsSignal TransductionCaspase 1ColchicineInterleukin-18NF-kappa BTubulin ModulatorsCaspase-1colchicineHIF-1αIL-18pyroptosis

Identifiers

PMID40951489
PMCPMC12425549

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.