Evidence map›Paper›PMID 40951472›Full record

ArticleNarra J2025

Thymoquinone and madecassoside improve motor function in a rotenone-induced mouse model of early Parkinson's disease: Role of dopamine, alpha-synuclein and mBDNF.

Shinta Kusumawati, Agustina T Endharti, Farhad Balafif, Shahdevi N Kurniawan, Aris Rosidah, Rabjhany Anaqah, Izzunazel A Barqillah, Husnul Khotimah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Narra J, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shinta KusumawatiDoctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Agustina T EndhartiDepartment of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Farhad BalafifDepartment of Neurosurgery, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Shahdevi N KurniawanDepartment of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Aris RosidahDepartement of Anatomical Pathology, Faculty of Medicine, Universitas Islam Malang, Malang, Indonesia.
Rabjhany AnaqahMaster Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Izzunazel A BarqillahFaculty of Medicine, Universitas Islam Malang, Malang, Indonesia.
Husnul KhotimahDepartment of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is a progressive, incurable neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and pathological aggregation of α-synuclein in the midbrain, leading to motor dysfunction. Thymoquinone (TQ), an active compound from

Indexed as

alpha-SynucleinBenzoquinonesBrain-Derived Neurotrophic FactorDopamineParkinson DiseaseTriterpenesAnimalsDisease Models, AnimalMaleMiceMotor ActivityNeuroprotective AgentsRotenonealpha-SynucleinBenzoquinonesBrain-Derived Neurotrophic FactorDopamineNeuroprotective AgentsRotenonethymoquinoneTriterpenesdopaminemotoricParkinsonthymoquinoneα-synuclein

Identifiers

PMID40951472
PMCPMC12425543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.