Evidence map›Paper›PMID 40951466›Full record

ArticleNarra J2025

Impact of walking exercise intensity on cartilage IL-1, TNF-α, IL-4, MMP-13 and pain threshold in osteoarthritis rat models.

Kusworini Handono, Dwi A Prasetyo, Nia Kurnianingsih, Cesarius S Wahono, Thoha M Albaar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Narra J, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kusworini HandonoDepartment of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Dwi A PrasetyoMaster Program in Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Nia KurnianingsihDepartment of Physiology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Cesarius S WahonoSaiful Anwar General Hospital, Malang, Indonesia.
Thoha M AlbaarSaiful Anwar General Hospital, Malang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pro-inflammatory cytokines produced by chondrocytes play a crucial role in activating matrix metalloproteinase-13 (MMP-13), leading to an imbalance between the synthesis and degradation of the extracellular matrix (ECM) in osteoarthritis (OA). Although regular walking exercise has been shown to reduce inflammatory cytokine levels in OA animal models, the optimal exercise intensity remains underexplored. Therefore, the aim of this study was to investigate the effects of different intensities of regular walking exercise on the levels of pro-inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α)), anti-inflammatory cytokine (interleukin-4 (IL-4)), as well as MMP-13 expression in cartilage and pain thresholds in an OA animal model. A total of 30 adult male

Indexed as

Matrix Metalloproteinase 13OsteoarthritisPain ThresholdPhysical Conditioning, AnimalWalkingAnimalsCartilage, ArticularDisease Models, AnimalInterleukin-1Interleukin-4MaleRatsTumor Necrosis Factor-alphaInterleukin-1Interleukin-4Matrix Metalloproteinase 13Tumor Necrosis Factor-alphacytokinesMMP-13Osteoarthritispainwalking exercise

Identifiers

PMID40951466
PMCPMC12425518

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.