Evidence map›Paper›PMID 40951440›Full record

SynthesisFrontiers in endocrinology2025

Dual-tracer

Jing Li

Abstract readCase ReportsSystematic Review
In one paragraph

Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jing LiDepartment of Nuclear Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: oncocytic thyroid adenoma (OA), a rare benign neoplasm, poses diagnostic challenges in conventional imaging modalities. The study investigates the diagnostic utility of dual-tracer Methods: We present a histopathologically confirmed OA case evaluated through simultaneous Results: A 44-year-old female presenting with ACTH-independent Cushing syndrome (morning cortisol 632.8 nmol/L, non-suppressed on dexamethasone suppression tests) underwent comprehensive endocrine evaluation. Incidentally detected thyroid nodule demonstrated discordant tracer uptake: Conclusion: This case demonstrates the complementary diagnostic value of dual-tracer PET/CT in OA characterization, particularly in SSTR2-negative variants. The discordant uptake patterns suggest distinct metabolic pathways in OA pathophysiology. Prospective multicenter studies with larger cohorts are warranted to establish standardized diagnostic criteria and explore theranostic applications of these imaging biomarkers in OA.

Indexed as

AdenomaAdenoma, OxyphilicFluorodeoxyglucose F18OctreotidePositron Emission Tomography Computed TomographyThyroid NeoplasmsAdultFemaleHumansRadiopharmaceuticalsFluorodeoxyglucose F18OctreotideRadiopharmaceuticals18F-AlF-NOTA-octreotide18F-fluorodeoxyglucoseoncocytic thyroid adenomaPET/CTsomatostatin receptors

Identifiers

PMID40951440
PMCPMC12425769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.