Trial reportFrontiers in endocrinology2025
Comparison of the efficacy of single vs. double autologous platelet-rich plasma intrauterine infusion on endometrial receptivity in thin endometrium patients: a prospective randomized controlled trial.
Trial report in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of platelet-rich plasma or plasma rich in growth factors in the treatment of thin endometrium: a systematic review and meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
- Investigation of the effect of intrauterine injection of platelet-rich plasma (PRP) on the results of in vitro fertilization (IVF): A cohort study.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Endometrial Repair and Regenerative Medicine: From Broad-Spectrum Regeneration to Precision Intervention.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management.Frontiers in reproductive health · 2026Review
- Endometrial hypoperfusion: the missing link in refractory thin endometrium.Frontiers in reproductive health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare single versus double autologous platelet-rich plasma (PRP) intrauterine infusion effects on endometrial receptivity and pregnancy outcomes in patients with thin endometrium. Methods: This randomized controlled trial included 100 patients with thin endometrium and infertility, assigned to single (n=50) or double (n=50) infusion groups. The single group received 1.0 ml of PRP on day 11 of the hormone replacement therapy-frozen embryo transfer (HRT-FET) cycle, while the double group received 1.0 ml on both days 11 and 13. Primary outcomes included endometrial thickness, receptivity changes, and clinical pregnancy rates; secondary outcomes were cycle cancellation rate, miscarriage rate, and endometrial hemodynamics. Statistical analysis was conducted using SPSS 26.0. Results: The double PRP infusion group exhibited measurable improvements in endometrial and early pregnancy outcomes. 1) Endometrial thickness increased (8.42 ± 0.53 mm vs 7.96 ± 0.45 mm, P<0.01); 2) Hemodynamic parameters improved for resistance index (RI) (1.72 ± 0.08 vs 1.79 ± 0.08, P<0.01) and pulsatility index (PI) (3.83 ± 0.64 vs 4.38 ± 0.68, P<0.01); 3) Clinical outcomes: lower cycle cancellation rate (10.0% vs 26.0%, P=0.037) and higher clinical pregnancy rate (48.9% vs 27.0%, P=0.043).However, early miscarriage rates were similar between groups (p > 0.99). Conclusion: Compared to a single intrauterine infusion, double intrauterine PRP infusion may enhance the receptivity of a thin endometrium and improve clinical pregnancy outcomes. However, since the study population did not include patients with thin endometrium who also have a history of recurrent implantation failure or recurrent miscarriage, caution is advised when applying these findings to this specific group. Furthermore, these conclusions require validation through larger, randomized, multicenter trials.
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