ReviewFrontiers in endocrinology2025
Osteosarcopenia: epidemiology, molecular mechanisms, and management.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Interorgan Crosstalk in MASLD: A Narrative Review.Biomedicines · 2026Review
- Osteosarcopenia in Cardiac Surgery: Standardization, Selection Bias, and Outcome Definition Matter.Geriatrics & gerontology international · 2026Article
- Integrative Analysis Coupled with In Vitro Validation RevealsInternational journal of molecular sciences · 2026Article
- Superficial femoral artery thrombosis after PFNA in an intertrochanteric fracture patient with sarcopenia and copd: a rare case report.BMC geriatrics · 2026Article
- Water Distribution in the Body as a Source of Information on Markers of Skeletal Muscle Ageing.Nutrients · 2026Article
- Opportunistic CT screening for osteosarcopenia predicts reduced overall survival in patients with gastric cancer: a retrospective cohort study.Journal of gastrointestinal oncology · 2026Article
- Frailty and sarcopenia as independent predictors of early functional recovery in older adults with osteoporotic vertebral compression fractures: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Beyond bone density: toward an integrated bone- muscle-function framework for fragility fracture prevention.Frontiers in medicine · 2026Article
- Physical exercise therapy as an anti-aging strategy for osteosarcopenia: a narrative review.Frontiers in aging · 2026Review
- Exploring osteosarcopenia from the gut microbiota perspective: mechanistic insights and therapeutic potentials based on the gut-muscle-bone Axis.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcopenia (OS), a recently recognized syndrome characterized by the simultaneous occurrence of osteopenia/osteoporosis and sarcopenia, has emerged as an important concept in clinical practice. This integrated framework provides a comprehensive view of the musculoskeletal system, addressing a previously underappreciated aspect of muscle health. OS notably increases the risk of falls, fractures, hospitalization, and mortality in elderly patients with chronic diseases. Despite its growing clinical relevance, OS remains underdiagnosed, and its classification as a distinct syndrome is not universally accepted. The persistently high global prevalence of chronic diseases, along with their substantial medical, economic, and social burdens, underscores the urgent need for updated prevention and management strategies. This review advocates for greater awareness and improved management of OS in patients with chronic diseases. It examines the relationship between OS and chronic conditions, emphasizing its epidemiology, adverse outcomes, diagnostic approaches, pathophysiology, and potential management strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.