ArticleFrontiers in endocrinology2025
Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association Between Glyco-Lipid Seven-Factor Index, a Novel Composite Glyco-Lipid Index, and Periodontitis: A Cross-Sectional Study.International dental journal · 2026Article
- Review
- Multi-omics integration reveals ANXA6-high γδ T cell-endothelial communication as a potential link between periodontitis and MASLD.NPJ systems biology and applications · 2026Article
- Evaluation of Salusin-α and Salusin-β Levels in Human Saliva Samples from Patients with Gingivitis and Periodontitis: A Cross-Sectional Study.Biomedicines · 2026Article
- Mechanisms underlying the role of the oral-gut-liver axis in the promotion of liver fibrosis by periodontal disease: an interacting network of inflammation, microbiota, and barrier function.Frontiers in cellular and infection microbiology · 2026Review
- Associations between periodontal disease-induced immune cell activation and energy metabolism.Frontiers in immunology · 2026Review
- Periodontitis and MASLD: a narrative review of the direct oral-hepatic pathway.Frontiers in cellular and infection microbiology · 2026Review
- Liver Disease and Periodontal Pathogens: A Bidirectional Relationship Between Liver and Oral Microbiota.Dentistry journal · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontitis is increasingly recognized as a risk factor for non-alcoholic fatty liver disease (NAFLD), yet the underlying mechanisms remain unclear. Oxidative stress and lipid metabolism dysregulation may serve as key pathological links. This study investigates the impact of periodontitis on NAFLD progression and identifies molecular targets involved in hepatic oxidative stress and lipid alterations. Materials and methods: A rat model of periodontitis was established via molar ligation. Hepatic pathology was assessed using histological staining, biochemical assays, and oxidative stress markers. Proteomic analysis identified differentially expressed proteins (DEPs) associated with lipid metabolism and inflammation. Functional enrichment analysis, protein-protein interaction (PPI) network construction, and hub proteins identification were conducted. Results: Periodontitis significantly exacerbated hepatic lipid accumulation, fibrosis, and oxidative stress. Proteomic analysis identified 244 DEPs enriched in metabolic and inflammatory pathways. PPI network analysis revealed ACOX1, DBT, ACAA2, and HADHA as hub proteins. Downregulation of these proteins correlated with impaired lipid oxidation and hepatocellular injury in periodontitis-induced NAFLD. Conclusion: Periodontitis accelerates NAFLD progression through oxidative stress and lipid metabolism dysfunction. ACOX1, DBT, ACAA2, and HADHA may serve as therapeutic targets. These findings highlight the importance of oral health in systemic metabolic disorders and suggest new intervention strategies.
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