ArticleFrontiers in endocrinology2025
The predictive value of the ultrasound grayscale ratio for identifying malignant thyroid nodules.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Purpose: To assess the clinical utility of ultrasound grayscale ratio (UGSR) in distinguishing between benign and malignant thyroid nodules. Methods: We conducted a retrospective analysis of patients diagnosed with thyroid nodules between January 2017 and December 2021. Malignancy and benignity were determined based on histopathology (biopsy or surgery) as the reference standard. Conventional ultrasonography (US) was performed to measure the maximum diameter of each nodule and assess positive features of the Chinese Thyroid Imaging Reporting and Data System (C-TIRADS). UGSR was calculated as the ratio of nodule grayscale value to surrounding thyroid parenchyma grayscale value, quantified using ImageJ software. Two experienced radiologists used ImageJ software for UGSR measurements. Logistic regression analysis examined the association between UGSR and thyroid malignancy. A receiver operating characteristic (ROC) curve analysis was conducted, and the area under the curve (AUC) was calculated to assess UGSR's effectiveness in distinguishing between benign and malignant thyroid nodules. The UGSR cut-off value was established through ROC curve analysis. Results: A total of 125 nodules (78 benign, 47 malignant) were evaluated. Significant differences were observed between benign and malignant nodules in maximum diameter ( Conclusion: UGSR demonstrated high specificity (92.31%) and reliability in differentiating malignant from benign thyroid nodules, suggesting its potential as a quantitative adjunct to ultrasound diagnosis, though sensitivity (63.83%) warrants combination with other features.
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