SynthesisFrontiers in endocrinology2025
Effect of nine different exercise interventions on insulin sensitivity in diabetic patients: a systematic review and mesh meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Effectiveness of community-based Baduanjin combined with resistance training on cardiometabolic risk factors in older adults with type 2 diabetes: a 16-week randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Heterogeneous associations between domain-specific physical activity and sarcopenia risk in diabetic adults: A causal forest analysis.The Journal of international medical research · 2026Article
- Exercise as a Programmable Regulator of Mitophagy Sensitivity in Aging Muscle and Age-Related Disease.IUBMB life · 2026Review
- Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives.Cell communication and signaling : CCS · 2026Review
- Effects of regular swimming exercise on caveolin, insulin signaling, and SREBP-1c in adipose tissue of high-fat-fed ovariectomized rats.Physical activity and nutrition · 2026Article
- Association between a clinical pharmacist-led multimodal remote medication intervention and individualized treatment outcomes in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Physical activity is associated with improved glycemic control but not with IL-6-glycemic interactions in type 2 diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to assess the impact of nine exercise interventions (resistance training [BT, ball training [BT], resistance + walking [RT+W alk], resistance + running [RT + Running], resistance + cycling [RT + bicycle], running, and Tai Chi) on insulin sensitivity in patients with diabetes. Methods: A systematic search of five databases (PubMed, EMBASE, Cochrane, Web of Science, and CNKI) for RCTs investigating the effects of exercise interventions on insulin sensitivity in patients with diabetes was conducted. The quality of the included studies was assessed using the Cochrane Manual version 5.1.0 Risk of Bias Assessment Tool (ROB). Data analysis software was used for the synthesis and analysis. Results: This Meta-analysis comprised 21 randomized controlled trials involving 1140 participants. Cycling significantly reduced the fasting glucose index in individuals with diabetes (SUCRA score=90.7%). Resistance exercise exhibited superior efficacy in enhancing insulin sensitivity compared with alternative interventions in patients with diabetes (SUCRA score=71.8%). Furthermore, the combination of resistance exercise and running resulted in a noteworthy decrease in HOMA-IR levels (SUCRA score=64.2%). Conclusion: Cycling, resistance training, and combined aerobic and resistance exercises have been shown to effectively enhance fasting blood glucose levels, insulin secretion, and insulin sensitivity in individuals with diabetes. However, additional studies with longer follow-up periods and more rigorous methodologies are required to further validate these findings. Systematic review registration: https://ww.crd.york.ac.uk/PROSPERO/, identifier CRD42023450107.
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