Evidence map›Paper›PMID 40951322›Full record

ArticleNature electronics2025

Monolithic three-dimensional neural probes from deterministic rolling of soft electronics.

Yi Qiang, Wen Gu, Dongyeol Jang, Yieljae Shin, Delin Shi, Kyung Jin Seo, Gen Li, Sandra Vinnikova, Shiqiang Wu, Aditya Iyer and 14 more

Abstract read
In one paragraph

Article in Nature electronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Three-dimensional microelectrode arrays forBiomedical engineering letters · 2026
    Review
  3. Article
  4. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yi QiangThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Wen GuDepartment of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA.
Dongyeol JangThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Yieljae ShinThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Delin ShiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Kyung Jin SeoThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Gen LiThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Sandra VinnikovaSchool of Mechanical & Aerospace Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.
Shiqiang WuDepartment of Neurological Surgery, Weill Cornell Medical College, New York, NY, 10065, USA.
Aditya IyerDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, 10065, USA.
Pietro ArtoniCenter for Life Science, Boston Children's Hospital, Boston, MA, 02115, USA.
Jaehyeon RyuThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Tianyu BaiThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Vaishnavi DhawanDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Maria MedallaDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA.
Douglas L RoseneDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA.
Tara L MooreDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA.
Abigail N KoppesDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Ryan KoppesDepartment of Bioengineering and Biology Engineering, Northeastern University, Boston, MA, 02115, USA.
Jyun-You LiouDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY, 10065, USA.
Chandramouli ChandrasekaranDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA.
Xinyan Tracy CuiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Shuodao WangSchool of Mechanical & Aerospace Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.
Hui FangThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.

Funding

Extracellular Vesicle treatment and age-related neuropathology in non-human primatesR01AG068168 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MOORE, TARA L · 2020 to 2024
$3.6M
Extracellular Vesicle treatment and age-related neuropathology in non-human primatesRF1AG068168 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MOORE, TARA L · 2025 to 2025
$3.3M
Mechanisms underlying extracellular vesicle mediated changes in inflammation, neural circuitry and plasticity following cortical injury in aged monkeysR01AG078460 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TARA L MOORE, Maria Medalla · 2022 to 2026
$3.2M
Efficiency and Safety of Microstimulation Via Different Electrode MaterialsR01NS110564 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2024
$3.1M
Multimodal Characterization of Prefrontal and Premotor Circuits Underlying Perceptual Decision Making in Therhesus MonkeyR01NS122969 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI, LUEBKE, JENNIFER I · 2021 to 2025
$3.1M
Neuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural InterfacesU01NS123668 · NINDS · DUKE UNIVERSITY · PI FANG, HUI, VIVENTI, JONATHAN · 2021 to 2024
$2.9M
Enhanced Bedside Microdialysis for TBIR01NS102725 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHAEL, ADRIAN C, PUCCIO, AVA M. · 2018 to 2022
$2.7M
Optimization and Delivery of Bioactive Coating for High Yield and Stable Neural RecordingU01NS113279 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2022
$2.4M
Prefrontal-cingulate functional networks in aging monkeys: neural circuit substrates of cognitive agingRF1AG083206 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOO, BANG-BON, MEDALLA, MARIA · 2023 to 2023
$2.3M
Investigation of Cognitive and Affective Deficits Post TBI Using Multimodal Flexible Neural ProbesR01NS136622 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XINYAN Tracy CUI, AMY K WAGNER · 2024 to 2026
$1.6M
Prefrontal-cingulate functional networks in aging monkeys: neural circuit substrates of cognitive agingR01AG083206 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Bang-Bon Koo, TARA L MOORE · 2026 to 2026
$771k
Organization and Dynamics of Premotor and Prefrontal Cortical Circuits Mediating Goal-Directed BehaviorR00NS092972 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI · 2018 to 2020
$747k
NEI NIH HHS R21 EY030710NIA NIH HHS R01 AG068168NIA NIH HHS R01 AG078460NIA NIH HHS R01 AG083206NIA NIH HHS RF1 AG068168NIA NIH HHS RF1 AG083206NINDS NIH HHS R00 NS092972NINDS NIH HHS R01 NS102725NINDS NIH HHS R01 NS110564NINDS NIH HHS R01 NS122969NINDS NIH HHS R01 NS136622NINDS NIH HHS R21 NS135361NINDS NIH HHS R56 NS112207NINDS NIH HHS U01 NS113279NINDS NIH HHS U01 NS123668
6 · The paper itself

Abstract

Cognition and behaviour rely on coordinated activity from neural circuits distributed across three-dimensions. However, typical probes for recording neural activity in the brain are limited to two-dimensional interfacing due to the planar semiconductor fabrication process. Here, we report a rolling-of-soft-electronics approach to create monolithic 3D neural probes with high scalability and design flexibility. Compared to previous stacking or assembly methods, the approach directly transforms a planar device into a 3D probe by leveraging the softness of flexible electrodes. The electrode shanks are initially fabricated in a single plane and then connected to flexible spacer. By varying features of the planar design, such as shank pitch and spacer layer thickness, the device can then be deterministically rolled into several versatile 3D probe designs containing hundreds of electrodes. With the system, we demonstrate single-unit spike recording

Identifiers

PMID40951322
PMCPMC12425490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.