Evidence map›Paper›PMID 40951293›Full record

ArticleResearch square2025

Evaluating the accuracy of point of care testing compared to standard laboratory testing among inborn infants in the neonatal intensive care unit.

Lindsay Holzapfel, Isha Parikh, Sepideh Saroukhani, Matthew Rysavy, Mar Romero-Lopez, Brian Chang

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lindsay HolzapfelUniversity of Texas, Houston Health Science Center.ORCID 0000-0002-1830-5705
Isha ParikhUniversity of Texas, Houston Health Science Center.
Sepideh SaroukhaniUniversity of Texas, Houston Health Science Center.
Matthew RysavyUniversity of Texas Health Science Center at Houston.ORCID 0000-0002-1209-6607
Mar Romero-LopezUniversity of Texas, Houston Health Science Center.ORCID 0000-0002-5890-7786
Brian ChangUniversity of Texas, Houston Health Science Center.

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Center for Clinical and Translational SciencesUM1TR004906 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Maria Eulalia Fernandez, LORNA H. MCNEILL · 2024 to 2026
$16.7M
NCATS NIH HHS UL1 TR003167NCATS NIH HHS UM1 TR004906
6 · The paper itself

Abstract

Objective: Point-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly beneficial for low-birth-weight infants. Methods: A retrospective cohort of 118 patients with paired POC and CL tests was performed within one hour during the first 14 postnatal days. Differences and agreement were assessed using paired t-tests and Lin's concordance correlation coefficient (CCC). Results: Differences were observed between POC and CL measurements: sodium (6.0 mEq/L, CCC = 0.57), potassium (0.1 mEq/dL, CCC = 0.82), chloride (4.4 mEq/L, CCC = 0.70), glucose (3.5 mg/dL, CCC = 0.97), hemoglobin (-0.04 g/dL, CCC = 0.98) and hematocrit (-0.6%, CCC = 0.97). Differences were consistent across lab results, gestational ages, birthweights, and clinical factors. Conclusions: POC results differed from CL results in sodium and chloride, with little difference in potassium, glucose, hemoglobin, and hematocrit. POC testing may reduce blood volume and provide rapid results for decision-making.

Identifiers

PMID40951293
PMCPMC12425080

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.