ArticleResearch square2025
Prolonged Hyperoxia Exposure is an Independent Predictor for Moderate to Severe Neurodevelopmental Impairment in Extremely Premature Neonates.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Retrospective cohort study of extremely preterm infants (< 28 weeks' gestational age and birth weight ≤ 1500 g) treated at a level IV academic hospital from January 2008 to July 2018 to assess if prolonged hyperoxia is an independent risk factor for severe neurodevelopmental impairment (NDI) or death. Among 546 former extremely preterm infants, 327 (59.9%) were exposed to prolonged hyperoxia. Prolonged hyperoxia was associated with increased odds of severe NDI or death (OR 1.77, 95% CI 1.01 to 3.14) after adjusting for risk factors. When the components of the primary outcome were analyzed separately, prolonged hyperoxia was not associated with severe NDI among survivors (OR 1.39, 95% CI 0.74 to 2.63) but was associated with death (OR 3.20, 95% CI 1.23 to 9.59). In conclusion, prolonged exposure to oxygen is a significant and independent risk factor for development of long-term moderate to severe NDI including death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.