Evidence map›Paper›PMID 40951290›Full record

ArticleResearch square2025

OPIOID-EXPRESSING B CELLS SILENCE TUMOR-INFILTRATING NOCICEPTOR NEURONS.

Tuany Eichwald, Maryam Ahmadi, Andre Martel Matos, Amin Reza Nikpoor, Karine Roversi, Mohammad Balood, Fendi Obuekwe, Marci L Nilsen, Ayana T Ruffin, Gabryella Pinheiro and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tuany EichwaldDepartment of Biomedical and Molecular Sciences, Queen's University. Kingston, Canada.
Maryam AhmadiDepartment of Pharmacology and Physiology, University de Montreal. Montreal, Canada.
Andre Martel MatosDepartment of Neurobiologyand Hillman Cancer Center, University of Pittsburgh. Pittsburgh, USA.
Amin Reza NikpoorDepartment of Biomedical and Molecular Sciences, Queen's University. Kingston, Canada.
Karine RoversiDepartment of Biomedical and Molecular Sciences, Queen's University. Kingston, Canada.
Mohammad BaloodDepartment of Pharmacology and Physiology, University de Montreal. Montreal, Canada.
Fendi ObuekweDepartment of Neurobiologyand Hillman Cancer Center, University of Pittsburgh. Pittsburgh, USA.
Marci L NilsenDepartment of Neurobiologyand Hillman Cancer Center, University of Pittsburgh. Pittsburgh, USA.
Ayana T RuffinDepartment of Neurobiologyand Hillman Cancer Center, University of Pittsburgh. Pittsburgh, USA.
Gabryella PinheiroDepartment of Biomedical and Molecular Sciences, Queen's University. Kingston, Canada.
Laura BrabenecDepartment of Physiology and Pharmacology, Karolinska Institutet. Solna, Sweden.ORCID https://orcid.org/0000-0002-1375-3349
Moutih RafeiDepartment of Pharmacology and Physiology, University de Montreal. Montreal, Canada.
Paola VermeerCancer Biology and Immunotherapies Group, Sanford Research. Sioux Falls, USA.ORCID https://orcid.org/0000-0003-2370-8223
Tullia C BrunoDepartment of Neurobiologyand Hillman Cancer Center, University of Pittsburgh. Pittsburgh, USA.ORCID https://orcid.org/0000-0002-6433-0207
Nicole N ScheffDepartment of Neurobiologyand Hillman Cancer Center, University of Pittsburgh. Pittsburgh, USA.ORCID 0000-0002-5587-4990
Sebastien TalbotDepartment of Biomedical and Molecular Sciences, Queen's University. Kingston, Canada.ORCID 0000-0001-9932-7174

Funding

Intra-tumoral neurons contribute to head and neck cancer painR01DE032712 · NIDCR · SANFORD RESEARCH/USD · PI Paola Drapkin Vermeer · 2023 to 2026
$1.8M
Overcoming Immunotherapy Resistance Through Opioid Antagonism in Head and Neck CancerR01DE033473 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Nicole N Scheff · 2024 to 2026
$1.7M
NIDCR NIH HHS R01 DE032712NIDCR NIH HHS R01 DE033473
6 · The paper itself

Abstract

Nociceptor neurons, which transmit pain signals, also regulate immunity by releasing immunomodulatory neuropeptides. In head and neck squamous cell carcinoma (HNSCC) and melanoma, our research has shown that tumor-innervating nociceptors modulate anti-tumor immunity through the release of calcitonin gene-related peptide (CGRP) and its interaction with receptor activity-modifying protein 1 (RAMP1). A retrospective analysis of clinical charts from HNSCC patients revealed that higher pain levels correlated with increased opioid use, perineural invasion, and decreased B-cell infiltration-factors associated with poorer survival outcomes.

Indexed as

B CellsCancer NeuroscienceHead and Neck CancerMelanomaNeuro-ImmunologyNociceptinPain

Identifiers

PMID40951290
PMCPMC12425075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.