Evidence map›Paper›PMID 40951278›Full record

ArticleResearch square2025

Genetic risk factors modulate the association between physical activity and colorectal cancer.

Anita R Peoples, Mireia Obón-Santacana, Andre E Kim, Eric S Kawaguchi, Yubo Fu, Conghui Qu, Ferran Moratalla-Navarro, John Morrison, Yi Lin, Volker Arndt and 64 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

74 authors.

Anita R PeoplesAmerican Cancer Society.
Mireia Obón-SantacanaCatalan Institute of Oncology (ICO), L'Hospitalet del Llobregat.
Andre E KimUniversity of Southern California.
Eric S KawaguchiUniversity of Southern California.
Yubo FuUniversity of Southern California.
Conghui QuFred Hutchinson Cancer Center.
Ferran Moratalla-NavarroCatalan Institute of Oncology (ICO), L'Hospitalet del Llobregat.
John MorrisonUniversity of Southern California.
Yi LinFred Hutchinson Cancer Center.
Volker ArndtGerman Cancer Research Center (DKFZ).
Sonja I BerndtNational Cancer Institute, National Institutes of Health.
Stephanie A BienFred Hutchinson Cancer Center.
D Timothy BishopUniversity of Leeds.
Emmanouil BourasUniversity of Ioannina School of Medicine.
Hermann BrennerGerman Cancer Research Center (DKFZ).
Daniel D BuchananThe University of Melbourne.
Peter T CampbellAlbert Einstein College of Medicine.
Andrew T ChanMassachusetts General Hospital, Harvard Medical School.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ).
David V ContiUniversity of Southern California.
Douglas Ac CorleyKaiser Permanente Northern California.
Matthew A DevallUniversity of Virginia.
Niki DimouInternational Agency for Research on Cancer, World Health Organization.
David A DrewMassachusetts General Hospital, Harvard Medical School.
Stephen B GruberCity of Hope National Medical Center.
Marc J GunterInternational Agency for Research on Cancer, World Health Organization.
Sophia HarlidUmeå University.
Tabitha A HarrisonFred Hutchinson Cancer Center.
Michael HoffmeisterGerman Cancer Research Center (DKFZ).
Li HsuFred Hutchinson Cancer Center.
Jeroen R HuygheFred Hutchinson Cancer Center.
Temitope O KekuUniversity of North Carolina.
Anshul KundajeStanford University.
Juan Pablo LewingerUniversity of Southern California.
Li LiUniversity of Virginia.
Brigid M LynchCancer Council Victoria.
Loic Le MarchandUniversity of Hawaii Cancer Center.
Vicente MartínUniversidad de León.
Neil MurphyInternational Agency for Research on Cancer, World Health Organization.
Christina C NewtonAmerican Cancer Society.
Shuji OginoBroad Institute of MIT and Harvard.
Sheetal HardikarHuntsman Cancer Institute.
Jennifer OseUniversity of Applied Sciences and Arts.
Rish K PaiMayo Clinic Arizona.
Julie R PalmerSlone Epidemiology Center at Boston University.
Nikos PapadimitriouInternational Agency for Research on Cancer, World Health Organization.
Bens PardameanBinus University.
Andrew J PellattUniversity of Texas MD Anderson Cancer Center.
Mila PinchevLady Davis Carmel Medical Center.
Elizabeth A PlatzJohns Hopkins Bloomberg School of Public Health.
John D PotterFred Hutchinson Cancer Center.
Gad RennertLady Davis Carmel Medical Center.
Edward A Ruiz-NarvaezUniversity of Michigan School of Public Health.
Lori C SakodaKaiser Permanente.
Robert E SchoenUniversity of Pittsburgh Medical Center.
Anna ShcherbinaStanford University.
Mariana C SternUniversity of Southern California.
Yu-Ru SuKaiser Permanente San Francisco Medical Center.
Claire E ThomasFred Hutchinson Cancer Center.
Yu TianGerman Cancer Research Center (DKFZ).
Konstantinos K TsilidisUniversity of Ioannina School of Medicine.
Caroline Y UmAmerican Cancer Society.
Franzel J B van DuijnhovenWageningen University & Research.
Bethany van GuelpenUmeå University.
Kala VisvanathanJohns Hopkins Bloomberg School of Public Health.
Jun WangUniversity of Southern California.
Emily WhiteFred Hutchinson Cancer Center.
Alicja WolkKarolinska Institutet.
Michael O WoodsMemorial University of Newfoundland, St. John's.
Anna H WuUniversity of Southern California.
Cornelia M UlrichHuntsman Cancer Institute.
Ulrike PetersFred Hutchinson Cancer Center.
W James GaudermanUniversity of Southern California.
Victor MorenoCatalan Institute of Oncology (ICO), L'Hospitalet del Llobregat.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FUCHS, CHARLES S · 1991 to 2009
$41.8M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Molecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8M
VALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5M
NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA066635NCI NIH HHS R01 CA072520NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA244588NCI NIH HHS R01 CA273198NCI NIH HHS R21 CA191312NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA084968NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074794NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201700006CNIA NIH HHS R01 AG083580NIDDK NIH HHS P30 DK034987NIEHS NIH HHS T32 ES013678NIH HHS S10 OD028685WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

Background: Physical activity (PA) is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene-PA interaction analysis. Methods: Using logistic regression and two-step and joint tests, we analyzed interactions between common genetic variants across the genome and PA in relation to CRC risk. Self-reported PA levels were categorized as active (≥ 8.75 MET-h/wk) vs. inactive (< 8.75 MET-h/wk) and as study- and sex-specific quartiles of activity. Results: PA had an overall protective effect on CRC (OR [active vs. inactive] = 0.85; 95%CI = 0.81-0.90). The two-step GxE method identified an interaction between rs4779584, an intergenic variant near the Conclusions: In summary, we identified two genetic variants that modified the association between PA and CRC risk. One of them, related to

Indexed as

colorectal cancergene-environment interactionGWASphysical activity

Identifiers

PMID40951278
PMCPMC12425077

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