Evidence map›Paper›PMID 40951270›Full record

ArticleResearch square2025

Diastolic Blood Pressure Rise During Valsalva as a Surrogate for Sympathetic Activation to Identify Functional Hyperadrenergic Postural Tachycardia Syndrome.

Surat Kulapatana, Luis E Okamoto, Stefano Rigo, Vasile Urechie, Thomas W Cayton, Ruijing E Han, Giris Jacob, William D Dupont, Raffaello Furlan, Italo Biaggioni and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Surat KulapatanaVanderbilt University School of Engineering.
Luis E OkamotoVanderbilt University Medical Center.
Stefano RigoHumanitas Clinical and Research Center IRCCS.
Vasile UrechiemyDoctorAngel Saga.
Thomas W CaytonVanderbilt University Medical Center.
Ruijing E HanVanderbilt University School of Engineering.
Giris JacobTel Aviv University School of Medicine.
William D DupontVanderbilt University Medical Center.
Raffaello FurlanHumanitas Clinical and Research Center IRCCS.
Italo BiaggioniVanderbilt University Medical Center.
André DiedrichVanderbilt University Medical Center.ORCID https://orcid.org/0000-0001-5643-0294

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Autonomic Determinants of Postural Tachycardia SyndromeR01HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2019 to 2022
$1.7M
NCATS NIH HHS UL1 TR002243NHLBI NIH HHS R01 HL142583
6 · The paper itself

Abstract

Purpose: Muscle sympathetic nerve activity (MSNA) is valuable for POTS management, but microneurography is clinically impractical. We investigated whether the Valsalva phase 2 diastolic blood pressure rise (DBP Methods: We included 21 POTS females and 22 healthy females to perform Valsalva and microneurography. MSNA spike rate was obtained using stationary wavelet transformation. The DBP Results: The DBP Conclusion: DBP

Indexed as

HyperadrenergicMSNAPOTSSympatheticValsalva

Identifiers

PMID40951270
PMCPMC12425072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.