Evidence map›Paper›PMID 40951269›Full record

ArticleResearch square2025

PFAS Exposure Induces Hearing Loss by Targeting Cochlear Hair Cells, Ribbon Synapses, and Spiral Ganglions.

Pankaj Bhatia, Katherine Roth, Zhao Yang, Michael Petriello, Samson Jamesdaniel

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Pankaj BhatiaWayne State University.
Katherine RothWayne State University.
Zhao YangWayne State University.
Michael PetrielloWayne State University.
Samson JamesdanielWayne State University.

Funding

Translational Research Support CoreP30ES036084 · NIEHS · WAYNE STATE UNIVERSITY · PI Melissa A Runge-Morris · 2024 to 2026
$5.2M
PFAS accelerate atherosclerosis through modulation of bile acid metabolismR01ES034407 · NIEHS · WAYNE STATE UNIVERSITY · PI Michael Curtis Petriello · 2023 to 2026
$2.3M
PFAS increases susceptibility to infection-mediated PTBR01ES035692 · NIEHS · WAYNE STATE UNIVERSITY · PI Michael Curtis Petriello · 2024 to 2026
$1.7M
NIEHS NIH HHS P30 ES036084NIEHS NIH HHS R01 ES034407NIEHS NIH HHS R01 ES035692
6 · The paper itself

Abstract

Background Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants linked to adverse health effects. Recent epidemiological data suggest an association between PFAS exposure and hearing impairment, but underlying mechanisms remain unclear. This study examined PFAS-induced auditory dysfunction using Ldlr

Indexed as

cochlear synaptopathyouter hair cell lossPFAS-induced hearing lossspiral ganglions

Identifiers

PMID40951269
PMCPMC12425078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.