Evidence map›Paper›PMID 40951243›Full record

ArticleCureus2025

The Ulcerative Effects of Levamisole-Induced Vasculitis.

Angela Zavaro, Azary Hernandez, Nadin Abboud, Seth Bleicher

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angela ZavaroInternal Medicine, Jackson Memorial Hospital, Miami, USA.
Azary HernandezInternal Medicine, Jackson Memorial Hospital, Miami, USA.
Nadin AbboudInternal Medicine, American University of the Caribbean School of Medicine, Miami, USA.
Seth BleicherInternal Medicine, Jackson Memorial Hospital, Miami, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levamisole-induced vasculitis is an autoimmune vasculitis that is most commonly associated with the use of levamisole-adulterated cocaine. We present a case of a 35-year-old undomiciled woman who was admitted to the inpatient psychiatric unit for drug detoxification and evaluation of bilateral lower extremity ulcerations. Her clinical presentation, along with a history of cocaine use, raised suspicion for levamisole-associated vasculitis. Symptomatic resolution and cutaneous healing in these cases are typically observed within 2-14 months following sustained abstinence from cocaine. This case highlights the growing concern for the lack of routine screening of drug adulterants such as levamisole in patients with known polysubstance abuse. To improve outcomes and reduce morbidity and mortality in this patient population, routine laboratory evaluation and diagnostic workup for adulterating agents should be incorporated into standard protocols. Additionally, comprehensive treatment plans should include nutritional support, wound care, and individualized addiction management strategies. Early recognition and targeted intervention are essential for optimizing care and promoting recovery in patients with substance use-related complications.

Indexed as

c-anca vasculitiscocaine adulterated with levamisolecocaine levamisole-induced vasculitisdrug-induced cutaneous vasculitismalnutritionpolysubstance use disorder

Identifiers

PMID40951243
PMCPMC12431897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.