Evidence map›Paper›PMID 40951219›Full record

ArticleCureus2025

Recurrent Spontaneous Hypothermia in an Elderly Woman: A Rare Neurological Case of Late-Onset Shapiro Syndrome.

Aye Thinzar Moe, Sujata Lama, Thi Han, Kyaw Soe Tun

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aye Thinzar MoeGeneral Medicine, King's College Hospital NHS Foundation Trust, London, GBR.
Sujata LamaGeneral Medicine, King's College Hospital NHS Foundation Trust, London, GBR.
Thi HanGeneral Medicine, King's College Hospital NHS Foundation Trust, London, GBR.
Kyaw Soe TunGeriatrics, King's College Hospital NHS Foundation Trust, London, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 81-year-old woman with a known diagnosis of Shapiro syndrome presented with recurrent hypothermia and delirium. This diagnosis had previously been made following multiple hospital admissions, extensive investigations, and imaging that showed corpus callosum agenesis. Shapiro syndrome is a rare neurological disorder characterised by episodic hypothermia and autonomic dysfunction. Management in this case was guided by an individualised care plan and supportive measures. This report highlights the diagnostic complexity of Shapiro syndrome and the importance of clinical awareness in older adults with unexplained hypothermia.

Indexed as

acute deliriumagenesis of the corpus callosumelderly peoplehypothermiashapiro syndrome

Identifiers

PMID40951219
PMCPMC12425428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.