ArticleCureus2025
Efficacy and Safety of Non-cross-Linked Hyaluronic Acid Injections for Facial Skin Biorevitalization: A Single-Center, Open-Label, Single-Arm, Uncontrolled, Post-marketing Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07010549 (Clinical and Instrumental Evaluation of the Face Biorevitalization Effect With the Medical Device Foliage Hydrofil), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Instrumental Evaluation of the Face Biorevitalization Effect With the Medical Device Foliage Hydrofil
Who cites it
2 citing papers in PubMed.
- A Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation.Clinical, cosmetic and investigational dermatology · 2026Article
- Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex.Clinical, cosmetic and investigational dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiorevitalization is a minimally invasive cosmetic procedure that involves the targeted intradermal injection of bioactive substances designed to enrich the skin and stimulate its natural regenerative capabilities. The aim of this single-center, open-label, single-arm, uncontrolled, post-marketing study was to examine the effectiveness and safety of biostimulatory injections using a proprietary, sterile gel containing non-cross-linked hyaluronic acid (Foliage Hydrofil
methodsThe trial was registered with ClinicalTrials.gov (NCT07010549). The intended target population comprised adults with mild-to-moderate facial photoaging and Fitzpatrick skin types III-IV, without active inflammatory dermatoses or recent aesthetic interventions. Twenty-four Caucasian subjects (21 women, three men; mean age: 44 ± 7.1 years) received three intradermal injections of the study product at three-week intervals. The primary endpoint was the change from baseline in skin capacitance, an objective measure of hydration, assessed via corneometry. Secondary endpoints included investigator and subject assessments of aesthetic improvement, while safety was evaluated through continuous adverse event monitoring.
resultsThe mean skin capacitance was 23.1 arbitrary units (a.u.) at baseline and increased to 33.2 a.u. at the end of the study, indicating a significant improvement in skin hydration (p < 0.05). Secondary outcomes showed moderate improvements in skin texture and tone, and high levels of participant satisfaction with the treatment. No adverse events were reported.
conclusionsThis study demonstrated that the tested non-cross-linked hyaluronic acid gel safely improves skin hydration and patient satisfaction in facial biorevitalization. Although promising, these findings are constrained by the study's uncontrolled, small-scale design; therefore, larger randomized controlled trials are required to confirm these outcomes and evaluate their long-term durability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.