ReviewCureus2025
Comparative Effectiveness of Fluid Resuscitation Strategies for Preventing Acute Kidney Injury in Critically Ill Patients: A Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a common complication in critically ill patients and is associated with high morbidity and mortality. This meta-analysis compares the effectiveness of different fluid resuscitation strategies in preventing AKI in critically ill patients. A systematic search was conducted in PubMed, MEDLINE, EMBASE, and the Cochrane database for randomized controlled trials comparing fluid resuscitation strategies in critically ill patients with AKI as an outcome. A random-effects meta-analysis was performed to calculate pooled ORs and risk ratios (RRs) with 95% CIs. Eight studies with 1,390 patients were included. There was no significant difference in AKI incidence between early goal-directed therapy (EGDT) and usual care (OR 0.90, 95% CI 0.71-1.13) or between crystalloids and colloids (OR 1.03, 95% CI 0.89-1.18). Mortality rates were similar between EGDT and usual care (RR 1.02, 95% CI 0.78-1.38) and between crystalloids and colloids (RR 1.03, 95% CI 0.93-1.14). The need for RRT did not differ significantly between strategies. Length of ICU stay was longer with EGDT than with usual care (MD 2.81 days, 95% CI 0.21-5.41), but was similar between crystalloids and colloids. This meta-analysis found no significant differences in AKI incidence, mortality, or need for RRT between fluid resuscitation strategies in critically ill patients. EGDT was associated with longer ICU stays compared to usual care. Further research is needed to optimize fluid management in critical care settings.
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