ArticleCureus2025
Fresh Platelet-Rich Plasma Gel Reduces Sciatic Nerve-Associated Neuropathic Pain in Rats by Suppressing Tumor Necrosis Factor-α and Interleukin-6 Expression.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The potential of platelet-rich plasma and PRP-derived biologics for neurological disorders: mechanisms and translational research.Frontiers in immunology · 2026Pooled it
- Therapeutic Efficacy of Combined Extracorporeal Shock Wave Therapy and Platelet-Rich Plasma Therapy in a Rat Model of Acute Achilles Tendinopathy.Orthopaedic journal of sports medicine · 2026Article
- TNFR-CD3-engineered regulatory T cells attenuate neuroinflammation and neuropathic pain.Immunologic research · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNerve wrapping using biomaterials has shown promising results in promoting nerve regeneration and improving functional outcomes in revision surgery cases. Our previous study on the local administration of basic fibroblast growth factor via a carrier demonstrated a limited effect. Thus, we have focused on platelet-rich plasma (PRP), a treatment material with recent evidence of tissue repair effects, and on a method of wrapping injured nerves by gelatinizing PRP without a carrier. However, there are few reports on studies targeting peripheral neuropathic pain. This study aimed to examine the efficacy and mechanism of action of this method. MATERIALS AND
methodsWistar rats were employed as a model of chronic constriction injury (CCI) and divided into two groups: CCI (untreated) and PRP-G (treated with PRP gel wrapping). PRP gels were prepared by centrifuging peripheral blood from other rats, followed by activation. Pain behavior test and real-time quantitative polymerase chain reaction of sciatic nerve RNA were conducted on postoperative days (PODs) three, seven, and 14 to quantify tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) (
resultsPathological evaluations of sciatic nerves performed on POD seven to investigate the neuroprotective effects of PRP gel wrapping revealed a significantly higher density of myelinated axons in the PRP-G group. In the CCI group after POD three, the pain threshold decreased to 0.88 ± 0.22 g, which was approximately one-third of the pre-treatment level, while the PRP-G group showed a pain threshold approximately twice that of the CCI group. Quantitative PCR results showed that, compared to untreated rats, both groups exhibited significantly increased expression of
conclusionsPRP gel wrapping has a substantial long-term suppression effect on neuropathic pain, possibly involving suppression of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.