ArticleCureus2025
Optogenetic Stimulation of Ca2+ Influx via Channelrhodopsin CapChR2 in Schwann Cells Promotes Neurite Outgrowth in Co-cultured PC12 Cells: A Neuronal Model.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nerve tissue model on a micropatterned surface: Axon guidance and neural regeneration.Journal of materials science. Materials in medicine · 2025Article
- Optogenetic and Endogenous Modulation of CaInternational journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSchwann cells (SCs) are essential players in peripheral nerve regeneration, contributing to both myelination and neuronal support via paracrine and contact-mediated mechanisms. Ca
methodsImmortalized Fischer rat SCs (IFRS1) were genetically modified to express CapChR2 and exposed to blue light. Intracellular Ca
resultsCapChR2-expressing IFRS1 showed an increase in intracellular Ca
conclusionOptogenetic activation of CapChR2-expressing IFRS1 successfully induced light-dependent Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.